Alexi Sarris

Alexei Sarris

Alexei Sarris

PhD student

Bio-organic Synthesis 
Leiden University
Einsteinweg 55 
2333 CC Leiden
The Netherlands
a.j.c.sarris@lic.leidenuniv.nl

Project

Cross-presentation of foreign protein fragments (epitopes) by major histocompatibility complex class I (MHC-I) receptors in antigen presenting cells plays an imporant role in the immune system. The exact routing and processing of these foreign proteins remains difficult to study.

The research I am working on during my PhD is to study how cross-presentation works from protein uptake to epitope presentation and T-cell response. By synthesis of Tetrazine/Alkene bio-orthogonal modified epitopes, peptides, proteasome inhibitors and fluorophores, this system will be visualised and studied in live cells to gain a better understanding of protein processing and cross-presentation by MHC-I receptors in antigen presenting cells.

Expertise

  • Organic Chemistry
  • Peptide Chemistry
  • Nucleotide Chemistry
  • Bio Chemistry
  • Analytical Chemistry (LC-MS, HP-LC, NMR, HR-MS)