Dennis Wander

Dennis Wander

Dennis Wander

PhD student

Bio-organic Synthesis
Leiden Institute of Chemistry,
Leiden University
Einsteinweg 55
2333 CC Leiden 
The Netherlands
d.p.a.wander@lic.leidenuniv.nl

Project 

Doxorubicin is part of the anthracycline class of chemotherapeutics. Their main mechanism of action was considered to be DNA double-strand breakage, leading to cell death. Recent experiments with GFP-tagged histones have shown that these compounds are able to kick out histones (including their post-translational modifications). For aclarubicin, this is the actual dominant mechanism instead.

An array of (oligo)-saccharides related to doxorubicin and aclarubicin will be synthesized through a shuffleable building-block approach. Combined with a cell-biology and bio-informatics pipeline, these compounds will be tested for their effectiveness and side-effects, as well as their potential as epigenetic modifiers.

Expertise

  • Synthesis
  • Deoxy-sugars
  • Anthracyclines
  • Glycosylation
  • Cancer