Sabina van der Zanden

Sabina van der Zanden

Sabina van der Zanden

PhD student

Leiden University Medical Center
Einthovenweg 20
2333 ZC Leiden
The Netherlands
S.Y.van_der_Zanden@lumc.nl

Project

My research project is focusing on the commonly used anthracycline anticancer drugs. By comparing these anthracyclines and their chemically modified analogues we aim to gain more inside in the intercalation and interaction of these molecules with DNA and their target topoisomerase II. Additionally, since it is known that the different anthracycline drugs have marked selectivity for specific genomic regions we hope by modifying these drugs to alter the regions targeted by these compounds, thereby expanding the subset of epigenetic modifiers.

Expertise

  • Molecular cell biology
  • Biochemistry
  • Confocal microscopy
  • Western blot analysis
  • ChIP- and FAIRE-sequencing analysis