Dennis Wander

Dennis Wander

Dennis Wander

PhD student

Bio-organic Synthesis
Leiden Institute of Chemistry,
Leiden University
Einsteinweg 55
2333 CC Leiden 
The Netherlands


Doxorubicin is part of the anthracycline class of chemotherapeutics. Their main mechanism of action was considered to be DNA double-strand breakage, leading to cell death. Recent experiments with GFP-tagged histones have shown that these compounds are able to kick out histones (including their post-translational modifications). For aclarubicin, this is the actual dominant mechanism instead.

An array of (oligo)-saccharides related to doxorubicin and aclarubicin will be synthesized through a shuffleable building-block approach. Combined with a cell-biology and bio-informatics pipeline, these compounds will be tested for their effectiveness and side-effects, as well as their potential as epigenetic modifiers.


  • Synthesis
  • Deoxy-sugars
  • Anthracyclines
  • Glycosylation
  • Cancer