Tim Hogervorst

Tim Hogervorst

PhD student

​Bio-organic Synthesis
Leiden University
Einsteinweg 55
2333 CC Leiden
The Netherlands


The goal of this project is to synthesize multifunctional single molecule vaccine modalities. In this project chemical synthesis is used  to access well-defined constructs comprising different immune-active components.  These components can include: an antigenic peptide (MHC I and II epitopes) for specific T cell induction and a combination of pathogen associated molecular patterns (PAMPs) such as Toll-like receptor (TLR) and C-type lectin receptors (CLRs) ligands. These constructs will be used to study the cross talk between CLRs and TLRs and optimize the immune response against the incorporated peptide antigen.


  • Carbohydrate synthesis,
  • Peptide synthesis
  • Organic chemistry
  • NMR spectroscopy
  • HPLC