Prodhi Manisha

PhD student
Molecular Cell Biology and Immunology
Research activities: 

Aberrant sialylation is a hallmark of the tumor microenvironment (TME), whereby upregulated sialic acids bind to inhibitory receptors and block anti-tumor responses. My project will involve the development of a multimodal conjugate therapeutic consisting of (1) an engineered sialidase to remove these sialic acids from the TME to incapacitate its ability for immune evasion, and (2) an antibody/nanobody to target the conjugate to tumor- and stroma-specific antigens. I will characterise sialidases for delivery, validate the stability of the conjugate in physiological conditions, and investigate its ability to induce immune responses in pancreatic cancer models in vitro and in vivo.