Tim Hogervorst

Project 

The goal of this project is to synthesize multifunctional single molecule vaccine modalities. In this project chemical synthesis is used  to access well-defined constructs comprising different immune-active components.  These components can include: an antigenic peptide (MHC I and II epitopes) for specific T cell induction and a combination of pathogen associated molecular patterns (PAMPs) such as Toll-like receptor (TLR) and C-type lectin receptors (CLRs) ligands. These constructs will be used to study the cross talk between CLRs and TLRs and optimize the immune response against the incorporated peptide antigen.

Expertise

• Carbohydrate synthesis,
• Peptide synthesis
• Organic chemistry
• NMR spectroscopy
• HPLC 

Thesis: Targeting of antigen presenting cells with mannosylated conjugates