Recent publications

An Environment-Sensitive Turn-On Fluorescent Probe Enables Detection of PAD4 Activation in Response to Distinct NETosis Stimuli

E.Ramos Cáceres; M.M. Bioch; M.L.W.J. Smeenk; R.C. Groß; K.M. Bonger

Year of Publication: 2026

Protocol to uncover the protein interactome of small non-coding vault RNAs through RNA antisense purification coupled to mass spectrometry

S.B. van der Kooij; J.E. Stok; A.G. van der Veen

Year of Publication: 2026

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

D. van der Vliet; L.E. de Vries; X. Di; D. Wever; B. de Jong; M.T.C. van der Meij; M. van der Peet; A.C. Harms; T. Hankemeier; D.F. Swaab; I. Huitinga; J. Verhaagen; M. van der Stelt

Year of Publication: 2026

Deciphering Stiffness-Driven Changes in Colorectal Cancer by Proteomics

C. Cresens; A. Montero-Calle; G. Solís-Fernández; B. Shaghaghi; L. Gerrits; S. Aytekin; P.H.J. Kouwer; R. Barderas; S. Rocha

Year of Publication: 2026

IL‐2 Free Expansion of T Cells with Immunofilaments

M. Schluck; L. Weiss; R. Classens; C.G. Figdor; R. Hammink

Year of Publication: 2026

Broadly neutralizing antibodies targeting pandemic GII.4 variants or seven GII genotypes of human norovirus

J. Park; L.C. Lindesmith; A.S. Olia; V.P. Costantini; P.D. Brewer-Jensen; M.L. Mallory; C.E. Kelley; E. Satterwhite; V. Longo; Y. Tsybovsky; T. Stephens; J. Marchioni; C.A. Martins; Y. Huang; R. Chaudhary; M. Zweigart; S.R. May; Y. Reyes; B. Flitter; J. Vinjé; S.N. Tucker; G.C. Ippolito; J.J. Lavinder; J. Snijder; P.D. Kwong; G. Georgiou; R.S. Baric

Year of Publication: 2025

Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry

D. Schulte; M. Šiborová; L. Käll; J. Snijder

Year of Publication: 2025

Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis

C.M. Wortel; R. van de Wetering; E.M. Stork; T. Kissel; S. Reijm; D. van der Woude; K.A. van Schie; L.A. Trouw; Y.K.O. Teng; A. Rutgers; P. Heeringa; R.E. Voll; M. Rizzi; N. Venhoff; R.E.M. Toes; H.U. Scherer

Year of Publication: 2025

Vault RNAs aid RNA virus infection by facilitating cytoplasmic localization of hnRNP C and ELAVL1

J.E. Stok; S.B. van der Kooij; D. Gravekamp; L.R. ter Haar; J.W. de Wolf; C. Salgado-Benvindo; T. Nelemans; B.J.M. Grijmans; R.T.N. Tjokrodirijo; A.H. de Ru; P.A. van Veelen; M.J. van Hemert; M. Kikkert; A.G. van der Veen

Year of Publication: 2025

Structural Basis for Postfusion-Specific Binding to the Respiratory Syncytial Virus F Protein by the Canonical Antigenic Site I Antibody 131–2a

W. Peng; M. Šiborová; X. Wu; W. Du; D. Schulte; M.F. Pronker; C.A.M. de Haan; J. Snijder

Year of Publication: 2025

Depleting Autoreactive B-Cells Using Targeted Photodynamic Therapy

K.R. Venrooij; T.Ioannis Papdimitriou; D.N. Dorst; K.M. Bonger

Year of Publication: 2025

A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics

D. Schulte; R.W. Leuvenink; S. Jager; A.J.R. Heck; J. Snijder

Year of Publication: 2025

Enhanced MHC Class‐II Expression in Fibroblastic Reticular Cells Associates with Maturation

J.E.G. Roet; C.Gago da Graça; M. de Kok; D. Panocha; T. Konijn; H.P. Roest; L.J.W. van der Laan; L.G.M. van Baarsen; C.M. de Winde; R.E. Mebius

Year of Publication: 2025

Leveraging Targeted Protein Degradation for G Protein-Coupled Receptors: The Development of CCR2 Molecular Degraders

K. Essa; N.V.Ortiz Zacarías; S. Roth; B.T. Xin; S. de Winter; C. van der Horst; B. Bleijs; R.A. de Heiden; R. Voulgaraki; E. Neubert; H. Ovaa; E.H.J. Danen; M.P.C. Mulder; K. Moreau; D. van der Es; L.H. Heitman

Year of Publication: 2025

Bioorthogonal click chemistry to visualize an immunogenic HLA-A2-restricted hepatitis B virus epitope in human monocyte-derived dendritic cellsAbstract

T.P. Mostert; A.L. Kessler; R.J. Luijten; W. Doelman; M.M.E. Isendoorn; D.V. Filippov; S.I. van Kasteren; S.I. Buschow

Year of Publication: 2025

Using BONCAT to dissect the proteome of S. aureus persisters

E.D.C.Geor Matlalcuatzi; T. Bakkum; P.S. Thomas; S. Hacker; B.I. Florea; B. Vriesendorp; D.E. Rozen; S.I. van Kasteren

Year of Publication: 2025

trans-Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity

A. Barendrecht; H.H.C. Peeters; D. Torres-García; T. Shema; A.J.C. Sarris; S. David; G. Aba; C.M. Le Gall; M. Wilkovitsch; M. Verdoes; H. Mikula; M.A. Travis; S.I. van Kasteren

Year of Publication: 2025

Proteome and Secretome Profiling of the Melanoma-Induced Transition Toward Immune Incompetent Dendritic Cells Reveals Enhanced IDO1, Cathepsin, and Legumain Activity

A.M.D. Becker; B.J. Ignacio; J.J. Dijkstra; A.R. Ziegler; I. Ramos-Tomillero; F.J. van Dalen; L.E. Edgington-Mitchell; M. Vermeulen; K.M. Bonger; J.M. de Vries; M. Verdoes

Year of Publication: 2025

Biomolecule Conjugation Strategy for HAGM Cryogels to Create 3D Immune Niches that Induce Multifunctional T CellsBiomolecule Conjugation Strategy for HAGM Cryogels to Create 3D Immune Niches that Induce Multifunctional T Cells

M. Schluck; J. Weiden; R. Hammink; L. Weiss; E.Vega Quiroz; M. Pfirrmann; L.Junquera Guinovart; V. van der Steen; C. Archidi; L.H. Minall; R. Classens; M. Rezaeeyazdi; T. Colombani; S.A. Bencherif; C.G. Figdor; M. Verdoes

Year of Publication: 2025

Interleukin-6 in synovial fluid drives the conversion of DC2s to DC3s in inflammatory arthritis

A.H. Decker; L.L. van den Hoogen; T. van Oorschot; L. Sanchez-Rocha; M.A. Boks; G. Bakdash; R. Thomas; C.D. Popa; M. Verdoes; R.M. Thurlings; A.M.D. Becker; J.M. de Vries

Year of Publication: 2025

Co-delivery of antigen and adjuvant by site-specific conjugation to dendritic cell-targeted Fab fragments potentiates T cell responses

Z. Wijfjes; I.Ramos Tomillero; C.M. Le Gall; E.A.W. van Dinther; F. Turlings; R. Classens; S. Manna; D. van Dalen; R.J.R.W. Peters; K. Schouren; F.L. Fennemann; I.M. Hagemans; F.J. van Dalen; J.M.S. van der Schoot; C.G. Figdor; A. Esser-Kahn; F.A. Scheeren; M. Verdoes

Year of Publication: 2025

Interleukin-12 decorated nanosized semiflexible Immunofilaments enable directed targeting and augmented IFNγ responses of natural killer cells

L. Weiss; M. Schluck; R. Classens; P.K.J.D. de Jonge; A. van der Waart; K.G. Nguyen; T.T. Nguyen; D.A. Zaharoff; K.J. Malmberg; H. Dolstra; C.G. Figdor; E. Sohlberg; R. Hammink

Year of Publication: 2025

Site-directed multivalent conjugation of antibodies to ubiquitinated payloads

A.F. el Hebieshy; Z. Wijfjes; C.M. Le Gall; J. Middelburg; K.E. de Roode; F.L. Fennemann; M. Sluijter; T. van Hall; D.J. Dijkstra; L.A. Trouw; F.J. van Dalen; A.Rodgers Furones; J.M.S. van der Schoot; I. Derksen; H. de Haard; B. van der Woning; C.M.P.Tala Ormeño; B.R. van Doodewaerd; C.G. Figdor; G.J. van der van Noort; P.W.H.I. Parren; S. Heskamp; H. Ovaa; M. Verdoes; F.A. Scheeren

Year of Publication: 2025

The conformation of tetraspanins CD53 and CD81 differentially affects their nanoscale organization and interaction with their partners

F. Schwerdtfeger; I. Hoogvliet; S. van Deventer; A.B. van Spriel

Year of Publication: 2024

Environment-sensitive turn-on fluorescent probe enables live cell imaging of myeloperoxidase activity during NETosis

E.Ramos Cáceres; L. Kemperman; K.M. Bonger

Year of Publication: 2024

Development of a Versatile Cancer Vaccine Format Targeting Antigen-Presenting Cells Using Proximity-Based Sortase A-Mediated Ligation of T-Cell Epitopes

A.Z. Wang; H.J. Brink; R.G. Bouma; A.J. Affandi; M.K.Nijen Twilhaar; D.A.M. Heijnen; J. van Elk; J.J. Maaskant; V.A.L. Konijn; J.G.C. Stolwijk; H. Kalay; K. Olesek; Y. van Kooyk; J.M.S. van der Schoot; A.E.H. Bentlage; F.A. Scheeren; M. Verdoes; G. Vidarsson; C.P. Kuijl; J.M.M. den Haan

Year of Publication: 2024

A neutralizing antibody prevents postfusion transition of measles virus fusion protein

D.S. Zyla; R.Della Marca; G. Niemeyer; G. Zipursky; K. Stearns; C. Leedale; E.B. Sobolik; H.M. Callaway; C. Hariharan; W. Peng; D. Parekh; T.C. Marcink; R.Diaz Avalos; B. Horvat; C. Mathieu; J. Snijder; A.L. Greninger; K.M. Hastie; S. Niewiesk; A. Moscona; M. Porotto; E.Ollmann Saphire

Year of Publication: 2024

Immunofilaments Are Well Tolerated after Local or Systemic Administration in Mice

L. Weiss; R. Classens; M. Schluck; E. Grad; Y. Dolen; L. van der Woude; D. van Midden; L. Maassen; K. Verrijp; K. van Riessen; E. van Dinther; P.M. Hagemann; C.G. Figdor; R. Hammink

Year of Publication: 2024

Oleic acid enhances proliferation and calcium mobilization of CD3/CD28 activated CD4+ T cells through incorporation into membrane lipids

J.Hendrick von Hegedus; A.J. de Jong; A.T. Hoekstra; E. Spronsen; W. Zhu; B. Cabukusta; J.C. Kwekkeboom; M. Heijink; E. Bos; C.R. Berkers; M.A. Giera; R.E.M. Toes; A. Ioan‐Facsinay

Year of Publication: 2024

Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously

K.R. Venrooij; L. de Bondt; K.M. Bonger

Year of Publication: 2024

Overcoming Barriers in Glioblastoma—Advances in Drug Delivery Strategies

Eter Linden; E.R. Abels; T.S. van Solinge; J. Neefjes; M.L.D. Broekman

Year of Publication: 2024

Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis

E.Maria Stork; D.M.H. van Rijswijck; K.A. van Schie; M. Hoek; T. Kissel; H.Ulrich Scherer; T.W.J. Huizinga; A.J.R. Heck; R.E.M. Toes; A. Bondt

Year of Publication: 2024

A Handle on Mass Coincidence Errors in De Novo Sequencing of Antibodies by Bottom-up Proteomics

D. Schulte; J. Snijder

Year of Publication: 2024

CRISPR-Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition

T.A.W. Schoufour; Avan der Pl van Duijn; I. Derksen; M. Melgers; J.M.F. van Veenendaal; C. Lensen; M.H.M. Heemskerk; J. Neefjes; R.H.M. Wijdeven; F.A. Scheeren

Year of Publication: 2024

Human lymph node fibroblastic reticular cells maintain heterogeneous characteristics in culture

J.E.G. Roet; A.I. Morrison; A.M. Mikula; M. de Kok; D. Panocha; H.P. Roest; L.J.W. van der Laan; C.M. de Winde; R.E. Mebius

Year of Publication: 2024

Unbiased method for spectral analysis of cells with great diversity of autofluorescence spectra

J.E.G. Roet; A.M. Mikula; M. de Kok; C.H. Chadick; J.J.Garcia Vallejo; H.P. Roest; L.J.W. van der Laan; C.M. de Winde; R.E. Mebius

Year of Publication: 2024

Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients

X. Qiao; S.Y. van der Zanden; X. Li; M. Tan; Y. Zhang; J.Y. Song; M.A. van Gelder; F.L. Hamoen; L. Janssen; C.L. Zuur; B. Pang; O. van Tellingen; J. Li; J. Neefjes

Year of Publication: 2024

Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

A. Petruzzella; M. Bruand; A. Santamaria-Martínez; N. Katanayeva; L. Reymond; S. Wehrle; S. Georgeon; D. Inel; F.J. van Dalen; D. Viertl; K. Lau; F. Pojer; M. Schottelius; V. Zoete; M. Verdoes; C. Arber; B.E. Correia; E. Oricchio

Year of Publication: 2024

Treg cells from human blood differentiate into non-lymphoid tissue-resident effector cells upon TNFR2 costimulation

M. Mensink; L.J. Verleng; E. Schrama; G.M.C. Janssen; R.T.N. Tjokrodirijo; P.A. van Veelen; Q. Jiang; F. Pascutti; M.L. van der Hoorn; M. Eikmans; S. de Kivit; J. Borst

Year of Publication: 2024

Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell

Y. Jia; M. Oyken; R.Q. Kim; R.T.N. Tjokrodirijo; A.H. de Ru; A.P.A. Janssen; S.M. Hacker; P.A. van Veelen; P.P. Geurink; A. Sapmaz

Year of Publication: 2024

The immunological landscape of peripheral blood in glioblastoma patients and immunological consequences of age and dexamethasone treatment

S.A. Dusoswa; J. Verhoeff; S. van Asten; J. Lübbers; M. van den Braber; S. Peters; S. Abeln; M.H.W. Crommentuijn; P. Wesseling; W.Peter Vandertop; J.W.R. Twisk; T. Würdinger; D. Noske; Y. van Kooyk; J.J. Garcia-Vallejo

Year of Publication: 2024

Membrane organization by tetraspanins and galectins shapes lymphocyte function

L.Querol Cano; V.M.E. Dunlock; F. Schwerdtfeger; A.B. van Spriel

Year of Publication: 2024

Gene and protein sequence features augment HLA class I ligand predictions

K. Bresser; B.P. Nicolet; A. Jeko; W. Wu; F. Loayza-Puch; R. Agami; A.J.R. Heck; M.C. Wolkers; T.N. Schumacher

Year of Publication: 2024

Into the Dark Serum Proteome: Personalized Features of IgG1 and IgA1 Repertoires in Severe COVID-19 Patients

A. Bondt; M. Hoek; K. Dingess; S. Tamara; B. de Graaf; W. Peng; M.A. den Boer; M. Damen; C. Zwart; A. Barendregt; D.M.H. van Rijswijck; D. Schulte; M. Grobben; K. Tejjani; J. van Rijswijk; F. Völlmy; J. Snijder; F. Fortini; A. Papi; C.Alberto Volta; G. Campo; M. Contoli; M.J. van Gils; S. Spadaro; P. Rizzo; A.J.R. Heck

Year of Publication: 2024

Structural Basis for Recognition of the FLAG-tag by Anti-FLAG M2

W. Beugelink; E. Sweep; B.J.C. Janssen; J. Snijder; M.F. Pronker

Year of Publication: 2024

Direct Comparison of the Hinge-Cleaving Proteases IgdE and BdpK for LC-MS-Based IgG1 Clonal Profiling

D.M.H. van Rijswijck; A. Bondt; N. de Kat; R. Lood; A.J.R. Heck

Year of Publication: 2024

Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

F.K. Kaiser; M.Gonzalez Hernandez; N. Krüger; E. Englund; W. Du; A.Z. Mykytyn; M.P. Raadsen; M.M. Lamers; F.Rodrigues Ianiski; T.M. Shamorkina; J. Snijder; F. Armando; G. Beythien; M. Ciurkiewicz; T. Schreiner; E. Gruber-Dujardin; M. Bleyer; O. Batura; L. Erffmeier; R. Hinkel; C. Rocha; M. Mirolo; D. Drabek; B.J. Bosch; M. Emalfarb; N. Valbuena; R. Tchelet; W. Baumgärtner; M. Saloheimo; S. Pöhlmann; F. Grosveld; B.L. Haagmans; A.D.M.E. Osterhaus

Year of Publication: 2024

Tailoring of Physical Properties in Macroporous Poly(isocyanopeptide) Cryogels

L. Gerrits; B. Bakker; L.D. Hendriks; S. Engels; R. Hammink; P.H.J. Kouwer

Year of Publication: 2024

Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing

W. Peng; K.C.A.P. Giesbers; M. Šiborová; W. Beugelink; M.F. Pronker; D. Schulte; J. Hilkens; B.J.C. Janssen; K. Strijbis; J. Snijder

Year of Publication: 2024

Inhibition of CSF-1R and IL-6R prevents conversion of cDC2s into immune incompetent tumor-induced DC3s boosting DC-driven therapy potential

A.M.D. Becker; A.H. Decker; G. Flórez-Grau; G. Bakdash; R.J. Röring; S. Stelloo; M. Vermeulen; B. Piet; E.H.J.G. Aarntzen; M. Verdoes; J.M. de Vries

Year of Publication: 2024

pH and ROS Responsiveness of Polymersome Nanovaccines for Antigen and Adjuvant Codelivery: An In Vitro and In Vivo Comparison

E. Jäger; O. Ilina; Y. Dolen; M. Valente; E.A.W. van Dinther; A. Jäger; C.G. Figdor; M. Verdoes

Year of Publication: 2024

Effect of Antigen Valency on Autoreactive B-Cell TargetingEffect of Antigen Valency on Autoreactive B-Cell Targeting

M.J. van Weijsten; K.R. Venrooij; L.P.W.M. Lelieveldt; T. Kissel; E. van Buijtenen; F.J. van Dalen; M. Verdoes; R.E.M. Toes; K.M. Bonger

Year of Publication: 2024