Recent publications

Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion

C. Le Gall; A. Cammarata; L. de Haas; I. Ramos-Tomillero; J. Cuenca-Escalona; K. Schouren; Z. Wijfjes; A.M.D. Becker; J. Bödder; Y. Dolen; J.M. de Vries; C.G. Figdor; G. Flórez-Grau; M. Verdoes

Year of Publication: 2022

Dictating Phenotype, Function, and Fate of Human T Cells with Co‐Stimulatory Antibodies Presented by Filamentous Immune Cell Mimics

M. Schluck; L.J. Eggermont; J. Weiden; C. Popelier; L. Weiss; B. Pilzecker; S. Kolder; A. Heinemans; C.Rodriguez Mogeda; M. Verdoes; C.G. Figdor; R. Hammink

Year of Publication: 2022

RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency

J.E. Stok; T. Oosenbrug; L.R. Haar; D. Gravekamp; C.P. Bromley; S. Zelenay; C.Reis e Sousa; A.G. Veen

Year of Publication: 2022

Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents

I.M. Hagemans; P.J. Wierstra; K. Steuten; J.D.M. Molkenboer-Kuenen; D. van Dalen; Mter Beest; J.M.S. van der Schoot; O. Ilina; M. Gotthardt; C.G. Figdor; F.A. Scheeren; S. Heskamp; M. Verdoes

Year of Publication: 2022

Frequency chasing of individual megadalton ions in an Orbitrap analyser improves precision of analysis in single-molecule mass spectrometry

T.P. Wörner; K. Aizikov; J. Snijder; K.L. Fort; A.A. Makarov; A.J.R. Heck

Year of Publication: 2022

Adeno-associated virus capsid assembly is divergent and stochastic

T.P. Wörner; A. Bennett; S. Habka; J. Snijder; O. Friese; T. Powers; M. Agbandje-McKenna; A.J.R. Heck

Year of Publication: 2021

Super-resolution correlative light-electron microscopy using a click-chemistry approach for studying intracellular trafficking

T. Andrian; T. Bakkum; D.M. van Elsland; E. Bos; A.J. Koster; L. Albertazzi; S.I. van Kasteren; S. Pujals

Year of Publication: 2021

Application of a Highly Selective Cathepsin S Two-step Activity-Based Probe in Multicolor Bio-Orthogonal Correlative Light-Electron MicroscopyDataSheet1.docxpresentation1.pptx

F.J. van Dalen; T. Bakkum; T. van Leeuwen; M. Groenewold; E. Deu; A.J. Koster; S.I. van Kasteren; M. Verdoes

Year of Publication: 2021

The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle‐down characterization of antibodies

T. Caval; E.S. Hecht; W. Tang; M. Uy‐Gomez; A. Nichols; Y.J. Kil; W. Sandoval; M. Bern; A.J.R. Heck

Year of Publication: 2021

Enhanced Antitumor Efficacy through an “AND gate” Reactive Oxygen‐Species‐Dependent pH‐Responsive Nanomedicine Approach

E. Jäger; J. Humajová; Y. Dolen; J. Kučka; A. Jäger; R. Konefał; J. Pankrác; E. Pavlova; T. Heizer; L. Šefc; M. Hrubý; C.G. Figdor; M. Verdoes

Year of Publication: 2021

Glycoproteoform Profiles of Individual Patients’ Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode

T. Caval; Y.H. Lin; M. Varkila; K.R. Reiding; M.J.M. Bonten; O.L. Cremer; V. Franc; A.J.R. Heck

Year of Publication: 2021

Synthetic (N,N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs

D.P.A. Wander; S.Y. van der Zanden; M.B.L. Vriends; B.C. van Veen; J.G.C. Vlaming; T. Bruyning; T. Hansen; G.A. van der Marel; H.S. Overkleeft; J.J.C. Neefjes; J.D.C. Codée

Year of Publication: 2021

Semiflexible Immunobrushes Induce Enhanced T Cell Activation and Expansion

R. Hammink; J. Weiden; D. Voerman; C. Popelier; L.J. Eggermont; M. Schluck; C.G. Figdor; M. Verdoes

Year of Publication: 2021

Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots

J. Weiden; M. Schluck; M. Ioannidis; E.A.W. van Dinther; M. Rezaeeyazdi; F. Omar; J. Steuten; D. Voerman; J. Tel; M. Diken; S.A. Bencherif; C.G. Figdor; M. Verdoes

Year of Publication: 2021

Human plasma IgG1 repertoires are simple, unique, and dynamic

A. Bondt; M. Hoek; S. Tamara; B. de Graaf; W. Peng; D. Schulte; D.M.H. van Rijswijck; M.A. den Boer; J.F. Greisch; M.R.J. Varkila; J. Snijder; O.L. Cremer; M.J.M. Bonten; A.J.R. Heck

Year of Publication: 2021

Single-cell analysis of regions of interest (SCARI) using a photosensitive tag

A.M. van der Leun; M.E. Hoekstra; L. Reinalda; C.L.G.J. Scheele; M. Toebes; M.J. van de Graaff; L.Y.Y. Chen; H. Li; A. Bercovich; Y. Lubling; E. David; D.S. Thommen; A. Tanay; J. van Rheenen; I. Amit; S.I. van Kasteren; T.N. Schumacher

Year of Publication: 2021

Targeting coenzyme Q10 synthesis overcomes bortezomib resistance in multiple myeloma

E.A. Zaal; H.J. de Grooth; I. Oudaert; P. Langerhorst; S. Levantovsky; G.J.J. van Slobbe; J.W.A. Jansen; E. Menu; W. Wu; C.R. Berkers

Year of Publication: 2021

Mass Spectrometry-Based De Novo Sequencing of Monoclonal Antibodies Using Multiple Proteases and a Dual Fragmentation Scheme

W. Peng; M.F. Pronker; J. Snijder

Year of Publication: 2021

Distinct antigen uptake receptors route to the same storage compartments for cross‐presentation in dendritic cells

N.I. Ho; M.G. Camps; J.J. Garcia‐Vallejo; E. Bos; A.J. Koster; M. Verdoes; Y. Kooyk; F. Ossendorp

Year of Publication: 2021

Immunoproteasome Inhibitor–Doxorubicin Conjugates Target Multiple Myeloma Cells and Release Doxorubicin upon Low-Dose Photon Irradiation

E. Maurits; M.J. van de Graaff; S. Maiorana; D.P.A. Wander; P.M. Dekker; S.Y. van der Zanden; B.I. Florea; J.J.C. Neefjes; H.S. Overkleeft; S.I. van Kasteren

Year of Publication: 2020

Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation

S. de Kivit; M. Mensink; A.T. Hoekstra; I. Berlin; R.J.E. Derks; D. Both; M.A. Aslam; D. Amsen; C.R. Berkers; J. Borst

Year of Publication: 2020

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin

X. Qiao; S.Y. van der Zanden; D.P.A. Wander; D.M. Borràs; J.Y. Song; X. Li; S. van Duikeren; N. van Gils; A. Rutten; T. van Herwaarden; O. van Tellingen; E. Giacomelli; M. Bellin; V. Orlova; L.G.J. Tertoolen; S. Gerhardt; J.J. Akkermans; J.M. Bakker; C.L. Zuur; B. Pang; A.M. Smits; C.L. Mummery; L. Smit; R. Arens; J. Li; H.S. Overkleeft; J. Neefjes

Year of Publication: 2020

IFN-Stimulated Gene 15 Is an Alarmin that Boosts the CTL Response via an Innate, NK Cell–Dependent Route

V. Iglesias-Guimarais; T. Ahrends; E. de Vries; K.P. Knobeloch; A. Volkov; J. Borst

Year of Publication: 2020

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

L.C. Demmers; K. Kretzschmar; A. Van Hoeck; Y.E. Bar-Epraïm; H.W.P. van den Toorn; M. Koomen; G. van Son; J. van Gorp; A. Pronk; N. Smakman; E. Cuppen; H. Clevers; A.J.R. Heck; W. Wu

Year of Publication: 2020

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

D.L. Hurdiss; I. Drulyte; Y. Lang; T.M. Shamorkina; M.F. Pronker; F.J.M. van Kuppeveld; J. Snijder; R.J. de Groot

Year of Publication: 2020

Self RNA Sensing by RIG-I–like Receptors in Viral Infection and Sterile Inflammation

J.E. Stok; E.Vega Quiroz; A.G. van der Veen

Year of Publication: 2020

Meta-heterogeneity: evaluating and describing the diversity in glycosylation between sites on the same glycoprotein

T. Caval; A.J.R. Heck; K.R. Reiding

Year of Publication: 2020

The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

S. Di Blasio; G.F. van Wigcheren; A. Becker; A. van Duffelen; M. Gorris; K. Verrijp; I. Stefanini; G.J. Bakker; M. Bloemendal; A. Halilovic; A. Vasaturo; G. Bakdash; S.V. Hato; J.H.W. de Wilt; J. Schalkwijk; I.J.M. de Vries; J.C. Textor; E.H. van den Bogaard; M. Tazzari; C.G. Figdor

Year of Publication: 2020

Opportunities for Small Molecules in Cancer Immunotherapy

S.Y. van der Zanden; J.J. Luimstra; J. Neefjes; J. Borst; H. Ovaa

Year of Publication: 2020

Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry

T.P. Wörner; J. Snijder; A. Bennett; M. Agbandje-McKenna; A.A. Makarov; A.J.R. Heck

Year of Publication: 2020

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications

T. Kissel; S. Reijm; L.M. Slot; M. Cavallari; C.M. Wortel; R.D. Vergroesen; G. Stoeken-Rijsbergen; J.C. Kwekkeboom; A.S.B. Kampstra; E.W.N. Levarht; J.W. Drijfhout; H. Bang; K.M. Bonger; G.M.C. Janssen; P.A. van Veelen; T.W.J. Huizinga; H.U. Scherer; M. Reth; R.E.M. Toes

Year of Publication: 2020

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

E.D. Mock; M. Mustafa; O. Gunduz-Cinar; R. Cinar; G.N. Petrie; V. Kantae; X. Di; D. Ogasawara; Z.V. Varga; J. Paloczi; C. Miliano; G. Donvito; A.C.M. van Esbroeck; A.M.F. van der Gracht; I. Kotsogianni; J.K. Park; A. Martella; T. van der Wel; M. Soethoudt; M. Jiang; T.J. Wendel; A.P.A. Janssen; A.T. Bakker; C.M. Donovan; L.I. Castillo; B.I. Florea; J. Wat; H. van den Hurk; M. Wittwer; U. Grether; A. Holmes; C.A.A. van Boeckel; T. Hankemeier; B.F. Cravatt; M.W. Buczynski; M.N. Hill; P. Pacher; A.H. Lichtman; M. van der Stelt

Year of Publication: 2020

Cross-talk between iNKT cells and CD8 T cells in the spleen requires the IL-4/CCL17 axis for the generation of short-lived effector cells

M. Valente; Y. Dölen; E. van Dinther; L. Vimeux; M. Fallet; V. Feuillet; C.G. Figdor

Year of Publication: 2019

Pre-fractionation Extends but also Creates a Bias in the Detectable HLA Class Ι Ligandome

L.C. Demmers; A.J.R. Heck; W. Wu

Year of Publication: 2019

Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second

L.M. Paardekooper; I. Dingjan; P.T.A. Linders; A.H.J. Staal; S.M. Cristescu; W.C.E.P. Verberk; G. van den Bogaart

Year of Publication: 2019

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

D.W. Vredevoogd; T. Kuilman; M.A. Ligtenberg; J. Boshuizen; K.E. Stecker; B. de Bruijn; O. Krijgsman; X. Huang; J.C.N. Kenski; R. Lacroix; R. Mezzadra; R. Gomez-Eerland; M. Yildiz; I. Dagidir; G. Apriamashvili; N. Zandhuis; V. van der Noort; N.L. Visser; C.U. Blank; M. Altelaar; T.N. Schumacher; D.S. Peeper

Year of Publication: 2019

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

A.C. Walls; X. Xiong; Y.J. Park; A. Tortorici; J. Snijder; J. Quispe; E. Cameroni; R. Gopal; M. Dai; A. Lanzavecchia; M. Zambon; F.A. Rey; D. Corti; D. Veesler

Year of Publication: 2019

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

J. Marcandalli; B. Fiala; S. Ols; M. Perotti; W. de van der Schueren; J. Snijder; E. Hodge; M. Benhaim; R. Ravichandran; L. Carter; W. Sheffler; L. Brunner; M. Lawrenz; P. Dubois; A. Lanzavecchia; F. Sallusto; K.K. Lee; D. Veesler; C.E. Correnti; L.J. Stewart; D. Baker; K. Loré; L. Perez; N.P. King

Year of Publication: 2019

Synthetic Semiflexible and Bioactive Brushes

D. Voerman; M. Schluck; J. Weiden; B. Joosten; L.J. Eggermont; T. van den Eijnde; B. Ignacio; A. Cambi; C.G. Figdor; P.H.J. Kouwer; M. Verdoes; R. Hammink; A.E. Rowan

Year of Publication: 2019

Production and Thermal Exchange of Conditional Peptide‐MHC I Multimers

J.J. Luimstra; K.L.M.C. Franken; M.A. Garstka; J.W. Drijfhout; J. Neefjes; H. Ovaa

Year of Publication: 2019

Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells

S.T.A. Koenders; L.S. Wijaya; M.N. Erkelens; A.T. Bakker; V.E. van der Noord; E.J. van Rooden; L. Burggraaff; P.C. Putter; E. Botter; K. Wals; H. van den Elst; Hden Dulk; B.I. Florea; B. van de Water; G.J.P. van Westen; R.E. Mebius; H.S. Overkleeft; S.E. Le Dévédec; M. van der Stelt

Year of Publication: 2019

Imaging of T-cells and their responses during anti-cancer immunotherapy

M. Krekorian; G.O. Fruhwirth; M. Srinivas; C.G. Figdor; S. Heskamp; T.H. Witney; E.H.J.G. Aarntzen

Year of Publication: 2019

Oxygen in the tumor microenvironment: effects on dendritic cell function

L.M. Paardekooper; W. Vos; G. van den Bogaart

Year of Publication: 2019

Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells

M. Schluck; R. Hammink; C.G. Figdor; M. Verdoes; J. Weiden

Year of Publication: 2019