Recent publications

The first step of peptide selection in antigen presentation by MHC class I molecules.

Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.

Polymer-based synthetic dendritic cells for tailoring robust and multifunctional T cell responses.

Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD).

Chemical profiling of the genome with anti-cancer drugs defines target specificities.

Bioorthogonal deprotection on the dendritic cell surface for chemical control of antigen cross-presentation.

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma.

N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging.

Chemical biology of antigen presentation by MHC molecules.

How chemistry supports cell biology: the chemical toolbox at your service.

The right touch: design of artificial antigen-presenting cells to stimulate the immune system

Peptide Splicing in the Proteasome Creates a Novel Type of Antigen with an Isopeptide Linkage.

Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules.

Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer

ER contact sites direct late endosome transport

A toolbox for controlling the properties and functionalisation of hydrazone-based supramolecular hydrogels

Variations in MHC Class II Antigen Processing and Presentation in Health and Disease

Characterization of the mammalian CORVET and HOPS complexes and their modular restructuring for endosome specificity.

Sampling from the proteome to the HLA-DR ligandome proceeds via high specificity

Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition.

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP)

A molecular basis for the presentation of phosphorylated peptides by HLA-B antigens

A large fraction of HLA class I ligands are proteasome-generated spliced peptides

Chemoenzymatic Approach for the Preparation of Asymmetric Bi-, Tri-, and Tetra-Antennary N-Glycans from a Common Precursor

Arginine (Di)methylated Human Leukocyte Antigen Class I Peptides Are Favorably Presented by HLA-B*07

Structural basis of myelin-associated glycoprotein adhesion and signalling

The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes

Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics

Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein

Imaging Bioorthogonal Groups in Their Ultrastructural Context with Electron Microscopy

Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance

Synthetic and semi-synthetic strategies to study ubiquitin signaling

Detection of bioorthogonal groups by correlative light and electron microscopy allows imaging of degraded bacteria in phagocytes

Extended O-GlcNAc on HLA Class-I-Bound Peptides

Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis

Inducible, Site-Specific Protein Labeling by Tyrosine Oxidation–Strain-Promoted (4 + 2) Cycloaddition

Retinoic Acid and Immune Homeostasis: A Balancing Act

Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope

SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis

Ethylene, an early marker of systemic inflammation in humans

Synthetic immune niches for cancer immunotherapy

Endolysosomal-Escape Nanovaccines through Adjuvant-Induced Tumor Antigen Assembly for Enhanced Effector CD8+ T Cell Activation

Toll-like Receptor Agonist Conjugation: A Chemical Perspective

Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells

ortho-Quinones and Analogues Thereof: Highly Reactive Intermediates for Fast and Selective Biofunctionalization

Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

Approaches to Improve Chemically Defined Synthetic Peptide Vaccines

Direct quality control of glycoengineered erythropoietin variants

Fast and pH independent elimination of trans-cyclooctene using aminoethyl functionalized tetrazines

Creating molecules that modulate immune responses

Ultrastructural Imaging of Salmonella-Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens

Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes

Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes

Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells

Approaches to Improve Chemically Defined Synthetic Peptide Vaccines

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

Antigen Processing and Cross-Presentation

Targeted analysis of lysosomal directed proteins and their sites of mannose-6-phosphate modification

Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor alpha via MAP3K8

Oxygen in the tumor microenvironment: effects on dendritic cell function

Pre-fractionation Extends but also Creates a Bias in the Detectable HLA Class Ι Ligandome

Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second

IFN-Stimulated Gene 15 Is an Alarmin that Boosts the CTL Response via an Innate, NK Cell–Dependent Route

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

Self RNA Sensing by RIG-I–like Receptors in Viral Infection and Sterile Inflammation

Meta-heterogeneity: evaluating and describing the diversity in glycosylation between sites on the same glycoprotein

The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin

Opportunities for Small Molecules in Cancer Immunotherapy

Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications

Cross-talk between iNKT cells and CD8 T cells in the spleen requires the IL-4/CCL17 axis for the generation of short-lived effector cells

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells

Imaging of T-cells and their responses during anti-cancer immunotherapy

Production and Thermal Exchange of Conditional Peptide‐MHC I Multimers

Synthetic Semiflexible and Bioactive Brushes

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

Immunoproteasome Inhibitor–Doxorubicin Conjugates Target Multiple Myeloma Cells and Release Doxorubicin upon Low-Dose Photon Irradiation

Glycoproteoform Profiles of Individual Patients’ Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode

The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle‐down characterization of antibodies

Enhanced Antitumor Efficacy through an “AND gate” Reactive Oxygen‐Species‐Dependent pH‐Responsive Nanomedicine Approach

Application of a Highly Selective Cathepsin S Two-step Activity-Based Probe in Multicolor Bio-Orthogonal Correlative Light-Electron MicroscopyDataSheet1.docxpresentation1.pptx

Super-resolution correlative light-electron microscopy using a click-chemistry approach for studying intracellular trafficking

Adeno-associated virus capsid assembly is divergent and stochastic

Synthetic (N,N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs

Semiflexible Immunobrushes Induce Enhanced T Cell Activation and Expansion

Distinct antigen uptake receptors route to the same storage compartments for cross‐presentation in dendritic cells

Human plasma IgG1 repertoires are simple, unique, and dynamic

Single-cell analysis of regions of interest (SCARI) using a photosensitive tag

Targeting coenzyme Q10 synthesis overcomes bortezomib resistance in multiple myeloma

Mass Spectrometry-Based De Novo Sequencing of Monoclonal Antibodies Using Multiple Proteases and a Dual Fragmentation Scheme

Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion

Frequency chasing of individual megadalton ions in an Orbitrap analyser improves precision of analysis in single-molecule mass spectrometry

Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents

RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency

Dictating Phenotype, Function, and Fate of Human T Cells with Co‐Stimulatory Antibodies Presented by Filamentous Immune Cell Mimics

Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots