All publications

Unbiased method for spectral analysis of cells with great diversity of autofluorescence spectra

J.E.G. Roet; A.M. Mikula; M. de Kok; C.H. Chadick; J.J.Garcia Vallejo; H.P. Roest; L.J.W. van der Laan; C.M. de Winde; R.E. Mebius

Year of Publication: 2024

Human lymph node fibroblastic reticular cells maintain heterogeneous characteristics in culture

J.E.G. Roet; A.I. Morrison; A.M. Mikula; M. de Kok; D. Panocha; H.P. Roest; L.J.W. van der Laan; C.M. de Winde; R.E. Mebius

Year of Publication: 2024

Effect of Antigen Valency on Autoreactive B-Cell TargetingEffect of Antigen Valency on Autoreactive B-Cell Targeting

M.J. van Weijsten; K.R. Venrooij; L.P.W.M. Lelieveldt; T. Kissel; E. van Buijtenen; F.J. van Dalen; M. Verdoes; R.E.M. Toes; K.M. Bonger

Year of Publication: 2024

CRISPR-Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition

T.A.W. Schoufour; Avan der Pl van Duijn; I. Derksen; M. Melgers; J.M.F. van Veenendaal; C. Lensen; M.H.M. Heemskerk; J. Neefjes; R.H.M. Wijdeven; F.A. Scheeren

Year of Publication: 2024

pH and ROS Responsiveness of Polymersome Nanovaccines for Antigen and Adjuvant Codelivery: An In Vitro and In Vivo Comparison

E. Jäger; O. Ilina; Y. Dolen; M. Valente; E.A.W. van Dinther; A. Jäger; C.G. Figdor; M. Verdoes

Year of Publication: 2024

A Handle on Mass Coincidence Errors in De Novo Sequencing of Antibodies by Bottom-up Proteomics

D. Schulte; J. Snijder

Year of Publication: 2024

Inhibition of CSF-1R and IL-6R prevents conversion of cDC2s into immune incompetent tumor-induced DC3s boosting DC-driven therapy potential

A.M.D. Becker; A.H. Decker; G. Flórez-Grau; G. Bakdash; R.J. Röring; S. Stelloo; M. Vermeulen; B. Piet; E.H.J.G. Aarntzen; M. Verdoes; J.M. de Vries

Year of Publication: 2024

Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis

E.Maria Stork; D.M.H. van Rijswijck; K.A. van Schie; M. Hoek; T. Kissel; H.Ulrich Scherer; T.W.J. Huizinga; A.J.R. Heck; R.E.M. Toes; A. Bondt

Year of Publication: 2024

Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing

W. Peng; K.C.A.P. Giesbers; M. Šiborová; W. Beugelink; M.F. Pronker; D. Schulte; J. Hilkens; B.J.C. Janssen; K. Strijbis; J. Snijder

Year of Publication: 2024

Overcoming Barriers in Glioblastoma—Advances in Drug Delivery Strategies

Eter Linden; E.R. Abels; T.S. van Solinge; J. Neefjes; M.L.D. Broekman

Year of Publication: 2024

Tailoring of Physical Properties in Macroporous Poly(isocyanopeptide) Cryogels

L. Gerrits; B. Bakker; L.D. Hendriks; S. Engels; R. Hammink; P.H.J. Kouwer

Year of Publication: 2024

Direct Comparison of the Hinge-Cleaving Proteases IgdE and BdpK for LC-MS-Based IgG1 Clonal Profiling

D.M.H. van Rijswijck; A. Bondt; N. de Kat; R. Lood; A.J.R. Heck

Year of Publication: 2024

Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously

K.R. Venrooij; L. de Bondt; K.M. Bonger

Year of Publication: 2024

Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

F.K. Kaiser; M.Gonzalez Hernandez; N. Krüger; E. Englund; W. Du; A.Z. Mykytyn; M.P. Raadsen; M.M. Lamers; F.Rodrigues Ianiski; T.M. Shamorkina; J. Snijder; F. Armando; G. Beythien; M. Ciurkiewicz; T. Schreiner; E. Gruber-Dujardin; M. Bleyer; O. Batura; L. Erffmeier; R. Hinkel; C. Rocha; M. Mirolo; D. Drabek; B.J. Bosch; M. Emalfarb; N. Valbuena; R. Tchelet; W. Baumgärtner; M. Saloheimo; S. Pöhlmann; F. Grosveld; B.L. Haagmans; A.D.M.E. Osterhaus

Year of Publication: 2024

Structural Basis for Recognition of the FLAG-tag by Anti-FLAG M2

W. Beugelink; E. Sweep; B.J.C. Janssen; J. Snijder; M.F. Pronker

Year of Publication: 2024

Oleic acid enhances proliferation and calcium mobilization of CD3/CD28 activated CD4+ T cells through incorporation into membrane lipids

J.Hendrick von Hegedus; A.J. de Jong; A.T. Hoekstra; E. Spronsen; W. Zhu; B. Cabukusta; J.C. Kwekkeboom; M. Heijink; E. Bos; C.R. Berkers; M.A. Giera; R.E.M. Toes; A. Ioan‐Facsinay

Year of Publication: 2024

Into the Dark Serum Proteome: Personalized Features of IgG1 and IgA1 Repertoires in Severe COVID-19 Patients

A. Bondt; M. Hoek; K. Dingess; S. Tamara; B. de Graaf; W. Peng; M.A. den Boer; M. Damen; C. Zwart; A. Barendregt; D.M.H. van Rijswijck; D. Schulte; M. Grobben; K. Tejjani; J. van Rijswijk; F. Völlmy; J. Snijder; F. Fortini; A. Papi; C.Alberto Volta; G. Campo; M. Contoli; M.J. van Gils; S. Spadaro; P. Rizzo; A.J.R. Heck

Year of Publication: 2024

Immunofilaments Are Well Tolerated after Local or Systemic Administration in Mice

L. Weiss; R. Classens; M. Schluck; E. Grad; Y. Dolen; L. van der Woude; D. van Midden; L. Maassen; K. Verrijp; K. van Riessen; E. van Dinther; P.M. Hagemann; C.G. Figdor; R. Hammink

Year of Publication: 2024

Gene and protein sequence features augment HLA class I ligand predictions

K. Bresser; B.P. Nicolet; A. Jeko; W. Wu; F. Loayza-Puch; R. Agami; A.J.R. Heck; M.C. Wolkers; T.N. Schumacher

Year of Publication: 2024

Membrane organization by tetraspanins and galectins shapes lymphocyte function

L.Querol Cano; V.M.E. Dunlock; F. Schwerdtfeger; A.B. van Spriel

Year of Publication: 2024

A neutralizing antibody prevents postfusion transition of measles virus fusion protein

D.S. Zyla; R.Della Marca; G. Niemeyer; G. Zipursky; K. Stearns; C. Leedale; E.B. Sobolik; H.M. Callaway; C. Hariharan; W. Peng; D. Parekh; T.C. Marcink; R.Diaz Avalos; B. Horvat; C. Mathieu; J. Snijder; A.L. Greninger; K.M. Hastie; S. Niewiesk; A. Moscona; M. Porotto; E.Ollmann Saphire

Year of Publication: 2024

The immunological landscape of peripheral blood in glioblastoma patients and immunological consequences of age and dexamethasone treatment

S.A. Dusoswa; J. Verhoeff; S. van Asten; J. Lübbers; M. van den Braber; S. Peters; S. Abeln; M.H.W. Crommentuijn; P. Wesseling; W.Peter Vandertop; J.W.R. Twisk; T. Würdinger; D. Noske; Y. van Kooyk; J.J. Garcia-Vallejo

Year of Publication: 2024

Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell

Y. Jia; M. Oyken; R.Q. Kim; R.T.N. Tjokrodirijo; A.H. de Ru; A.P.A. Janssen; S.M. Hacker; P.A. van Veelen; P.P. Geurink; A. Sapmaz

Year of Publication: 2024

Treg cells from human blood differentiate into non-lymphoid tissue-resident effector cells upon TNFR2 costimulation

M. Mensink; L.J. Verleng; E. Schrama; G.M.C. Janssen; R.T.N. Tjokrodirijo; P.A. van Veelen; Q. Jiang; F. Pascutti; M.L. van der Hoorn; M. Eikmans; S. de Kivit; J. Borst

Year of Publication: 2024

Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

A. Petruzzella; M. Bruand; A. Santamaria-Martínez; N. Katanayeva; L. Reymond; S. Wehrle; S. Georgeon; D. Inel; F.J. van Dalen; D. Viertl; K. Lau; F. Pojer; M. Schottelius; V. Zoete; M. Verdoes; C. Arber; B.E. Correia; E. Oricchio

Year of Publication: 2024

Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients

X. Qiao; S.Y. van der Zanden; X. Li; M. Tan; Y. Zhang; J.Y. Song; M.A. van Gelder; F.L. Hamoen; L. Janssen; C.L. Zuur; B. Pang; O. van Tellingen; J. Li; J. Neefjes

Year of Publication: 2024

Direct Mass Spectrometry-Based Detection and Antibody Sequencing of Monoclonal Gammopathy of Undetermined Significance from Patient Serum: A Case Study

W. Peng; M.A. den Boer; S. Tamara; N.J. Mokiem; S.P.A. van der Lans; A. Bondt; D. Schulte; P.J. Haas; M.C. Minnema; S.H.M. Rooijakkers; A.D. van Zuilen; A.J.R. Heck; J. Snijder

Year of Publication: 2023

Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection

C.M. Spruit; I.R. Sweet; J.C.L. Maliepaard; T. Bestebroer; P. Lexmond; B. Qiu; M.J.A. Damen; R.A.M. Fouchier; K.R. Reiding; J. Snijder; S. Herfst; G.J. Boons; R.P. de Vries

Year of Publication: 2023

Autoreactive B cells in rheumatoid arthritis include mainly activated CXCR3+ memory B cells and plasmablasts

S. Reijm; J.C. Kwekkeboom; N.J. Blomberg; J. Suurmond; D. van der Woude; R.E.M. Toes; H.U. Scherer

Year of Publication: 2023

N-Glycosylation-dependent regulation of immune-specific tetraspanins CD37 and CD53

S. van Deventer; I.A. Hoogvliet; M. van de Voort; F. Arnold; Mter Beest; A.B. van Spriel

Year of Publication: 2023

High Rates of Quinone‐Alkyne Cycloaddition Reactions are Dictated by Entropic Factors

J.A.M. Damen; J. Escorihuela; H. Zuilhof; F.L. van Delft; B. Albada

Year of Publication: 2023

PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance

M. van Gulijk; A. van Krimpen; S. Schetters; M. Eterman; M. van Elsas; J. Mankor; L. Klaase; M. de Bruijn; M. van Nimwegen; T. van Tienhoven; W. van Ijcken; L. Boon; J. van der Schoot; M. Verdoes; F. Scheeren; S.H. van der Burg; B.N. Lambrecht; R. Stadhouders; F. Dammeijer; J. Aerts; T. van Hall

Year of Publication: 2023

Dynamic Covalent Dextran Hydrogels as Injectable, Self-Adjuvating Peptide Vaccine Depots

B. Fan; D.Torres García; M. Salehi; M.J. Webber; S.I. van Kasteren; R. Eelkema

Year of Publication: 2023

Age-associated systemic factors change central and peripheral immunity in adult male mice

L. van Olst; A. Kamermans; S.M.A. van der Pol; E. Rodríguez; L.A. Hulshof; R.E. van Dijk; D.N. Vonk; M. Schouten; M.E. Witte; H.E. de Vries; J. Middeldorp

Year of Publication: 2023

Sialoglycan binding triggers spike opening in a human coronavirus

M.F. Pronker; R. Creutznacher; I. Drulyte; R.J.G. Hulswit; Z. Li; F.J.M. van Kuppeveld; J. Snijder; Y. Lang; B.J. Bosch; G.J. Boons; M. Frank; R.J. de Groot; D.L. Hurdiss

Year of Publication: 2023

MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression

B. Schrörs; B.J. Hos; I.G. Yildiz; M. Löwer; F. Lang; C. Holtsträter; J. Becker; M. Vormehr; U. Sahin; F. Ossendorp; M. Diken

Year of Publication: 2023

Maintaining soluble protein homeostasis between nuclear and cytoplasmic compartments across mitosis

S.Y. van der Zanden; M.L.M. Jongsma; A.C.M. Neefjes; I. Berlin; J. Neefjes

Year of Publication: 2023

Using click chemistry to study microbial ecology and evolution

S. van Kasteren; D.E. Rozen

Year of Publication: 2023

THRONCAT: metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog

B.J. Ignacio; J. Dijkstra; N. Mora; E.F.J. Slot; M.J. van Weijsten; E. Storkebaum; M. Vermeulen; K.M. Bonger

Year of Publication: 2023

Controlling Antigen Fate in Therapeutic Cancer Vaccines by Targeting Dendritic Cell Receptors

Z. Wijfjes; F.J. van Dalen; C.M. Le Gall; M. Verdoes

Year of Publication: 2023

Balanced Epigenetic Regulation of MHC Class I Expression in Tumor Cells by the Histone Ubiquitin Modifiers BAP1 and PCGF1

R.H. Wijdeven; S.J. Luk; T.A.W. Schoufour; S.Y. van der Zanden; M. Cabezuelo; M.H.M. Heemskerk; J. Neefjes

Year of Publication: 2023

Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2

J. Gan; J. de Vries; J.J.L.L. Akkermans; Y. Mohammed; R.T.N. Tjokrodirijo; A.H. de Ru; R.Q. Kim; D.A. Vargas; V. Pol; R. Fasan; P.A. van Veelen; J. Neefjes; H. van Dam; H. Ovaa; A. Sapmaz; P.P. Geurink

Year of Publication: 2023

Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B

Y. Wu; P. Mumford; S. Noy; K. Cleverley; A. Mrzyglod; D. Luo; F. van Dalen; M. Verdoes; E.M.C. Fisher; F.K. Wiseman

Year of Publication: 2023

USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism

J. Gan; A. Pinto-Fernández; D. Flierman; J.J.L.L. Akkermans; D.P. O’Brien; H. Greenwood; H.Claire Scott; G. Fritz; K.P. Knobeloch; J. Neefjes; H. van Dam; H. Ovaa; H.L. Ploegh; B.M. Kessler; P.P. Geurink; A. Sapmaz

Year of Publication: 2023

Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

L. Weiss; J. Weiden; Y. Dolen; E.M. Grad; E.A.W. van Dinther; M. Schluck; L.J. Eggermont; G. van Mierlo; U. Gileadi; A. Bartoló-Ibars; R. Raavé; M.A.J. Gorris; L. Maassen; K. Verrijp; M. Valente; B. Deplancke; M. Verdoes; D. Benitez-Ribas; S. Heskamp; A.B. van Spriel; C.G. Figdor; R. Hammink

Year of Publication: 2023

Addressing the key issue: Antigen-specific targeting of B cells in autoimmune diseases

M.D. Holborough-Kerkvliet; S. Kroos; R. van de Wetering; R.E.M. Toes

Year of Publication: 2023

Insights in the host response towards biomaterial-based scaffolds for cancer therapy

M. Schluck; J. Weiden; M. Verdoes; C.G. Figdor

Year of Publication: 2023

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

V. Thijssen; D.L. Hurdiss; O.J. Debski-Antoniak; M.A. Spence; C. Franck; A. Norman; A. Aggarwal; N.J. Mokiem; D.A.A. van Dongen; S.W. Vermeir; M. Liu; W. Li; M. Chatziandreou; T. Donselaar; W. Du; I. Drulyte; B.J. Bosch; J. Snijder; S.G. Turville; R.J. Payne; C.J. Jackson; F.J.M. van Kuppeveld; S.A.K. Jongkees

Year of Publication: 2023

A photoaffinity glycan-labeling approach to investigate immunoglobulin glycan-binding partners

M.D. Holborough-Kerkvliet; G. Mucignato; S.J. Moons; V. Psomiadou; R.S.R. Konada; N.J. Pedowitz; M.R. Pratt; T. Kissel; C.A.M. Koeleman; R.T.N. Tjokrodirijo; P.A. van Veelen; T. Huizinga; K.A.J. van Schie; M. Wuhrer; J.J. Kohler; K.M. Bonger; T.J. Boltje; R.E.M. Toes

Year of Publication: 2023

A Lysosome-Targeted Tetrazine for Organelle-Specific Click-to-Release Chemistry in Antigen Presenting Cells

N.A.M. Ligthart; M.A.R. de Geus; M.A.T. van de Plassche; D.Torres García; M.M.E. Isendoorn; L. Reinalda; D. Ofman; T. van Leeuwen; S.I. van Kasteren

Year of Publication: 2023

CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1

B. Miao; Z. Hu; R. Mezzadra; L. Hoeijmakers; A. Fauster; S. Du; Z. Yang; M. Sator-Schmitt; H. Engel; X. Li; C. Broderick; G. Jin; R. Gomez-Eerland; L. Rozeman; X. Lei; H. Matsuo; C. Yang; I. Hofland; D. Peters; A. Broeks; E. Laport; A. Fitz; X. Zhao; M.A.A. Mahmoud; X. Ma; S. Sander; Hkun Liu; G. Cui; Y. Gan; W. Wu; Y. Xiao; A.J.R. Heck; W. Guan; S.W. Lowe; H.M. Horlings; C. Wang; T.R. Brummelkamp; C.U. Blank; T.N.M. Schumacher; C. Sun

Year of Publication: 2023

CRISPR/Cas9-based Engineering of Immunoglobulin Loci in Hybridoma Cells

C. Le Gall; F. Fennemann; J. van der Schoot; F. Scheeren; M. Verdoes

Year of Publication: 2023

QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations

L.R. Pelgrom; G.M. Davis; S. O’Shaughnessy; E.J.M. Wezenberg; S.I. van Kasteren; D.K. Finlay; L.V. Sinclair

Year of Publication: 2023

Re-Exploring the Anthracycline Chemical Space for Better Anti-Cancer Compounds

M.A. van Gelder; S.Y. van der Zanden; M.B.L. Vriends; R.A. Wagensveld; G.A. van der Marel; J.D.C. Codée; H.S. Overkleeft; D.P.A. Wander; J.J.C. Neefjes

Year of Publication: 2023

Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins

W. van Bergen; A.J.R. Heck; M.P. Baggelaar

Year of Publication: 2022

Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA

B.J. Hos; E. Tondini; M.G.M. Camps; W. Rademaker; J. van den Bulk; D. Ruano; G.M.C. Janssen; A.H. de Ru; P.J. van den Elsen; N.F.C.C. de Miranda; P.A. van Veelen; F. Ossendorp

Year of Publication: 2022

The identification of the anthracycline aclarubicin as an effective cytotoxic agent for pancreatic cancer

T.P. Brouwer; S.Y. van der Zanden; M. van der Ploeg; J.D.H. van Eendenburg; B.A. Bonsing; N.F.C.C. de Miranda; J.J. Neefjes; A.L. Vahrmeijer

Year of Publication: 2022

Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern

D.M.H. van Rijswijck; A. Bondt; M. Hoek; K. van der Straten; T.G. Caniels; M. Poniman; D. Eggink; C. Reusken; G.J. de Bree; R.W. Sanders; M.J. van Gils; A.J.R. Heck

Year of Publication: 2022

Enzyme‐Activatable Chemokine Conjugates for In Vivo Targeting of Tumor‐Associated Macrophages

N.D. Barth; F.J. van Dalen; U. Karmakar; M. Bertolini; L. Mendive‐Tapia; T. Kitamura; M. Verdoes; M. Vendrell

Year of Publication: 2022

Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function

V.M.E. Dunlock; A.B. Arp; S.Pal Singh; S. Charrin; V. Nguyen; E. Jansen; F. Schaper; Mter Beest; M. Zuidscherwoude; S.J. van Deventer; B. Nakken; P. Szodoray; M.C. Demaria; M.D. Wright; L.Querol Cano; E. Rubinstein; A.B. van Spriel

Year of Publication: 2022

Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes

C. Wang; E.L. Hesketh; T.M. Shamorkina; W. Li; P.J. Franken; D. Drabek; R. van Haperen; S. Townend; F.J.M. van Kuppeveld; F. Grosveld; N.A. Ranson; J. Snijder; R.J. de Groot; D.L. Hurdiss; B.J. Bosch

Year of Publication: 2022

Artificial Antigen-Presenting Cell Topology Dictates T Cell Activation

A.C. Wauters; J.F. Scheerstra; I.G. Vermeijlen; R. Hammink; M. Schluck; L. Woythe; H. Wu; L. Albertazzi; C.G. Figdor; J. Tel; L.K.E.A. Abdelmohsen; J.C.M. van Hest

Year of Publication: 2022

Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437

B. Gagestein; A.F. Stevens; D. Fazio; B.I. Florea; T. van der Wel; A.T. Bakker; F. Fezza; Hden Dulk; H.S. Overkleeft; M. Maccarrone; M. van der Stelt

Year of Publication: 2022

Inhibitory prodrug mechanism for cysteine cathepsin-targeted self-controlled drug release

F.J. van Dalen; M. Verdoes

Year of Publication: 2022

Comparative Photoaffinity Profiling of Omega-3 Signaling Lipid Probes Reveals Prostaglandin Reductase 1 as a Metabolic Hub in Human Macrophages

B. Gagestein; J.H. von Hegedus; J.C. Kwekkeboom; M. Heijink; N. Blomberg; T. van der Wel; B.I. Florea; H. van den Elst; K. Wals; H.S. Overkleeft; M. Giera; R.E.M. Toes; A. Ioan-Facsinay; M. van der Stelt

Year of Publication: 2022

Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody

M.J. van Elsas; J.M.S. van der Schoot; A. Bartels; K. Steuten; D. van Dalen; Z. Wijfjes; C.G. Figdor; T. van Hall; S.H. van der Burg; M. Verdoes; F.A. Scheeren

Year of Publication: 2022

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

D.L. Hurdiss; P.El Kazzi; L. Bauer; N. Papageorgiou; F.P. Ferron; T. Donselaar; A.L.W. van Vliet; T.M. Shamorkina; J. Snijder; B. Canard; E. Decroly; A. Brancale; T. Zeev-Ben-Mordehai; F. Förster; F.J.M. van Kuppeveld; B. Coutard

Year of Publication: 2022

Multifunctional, Multivalent PIC Polymer Scaffolds for Targeting Antigen-Specific, Autoreactive B Cells

H. Kristyanto; M.D. Holborough-Kerkvliet; L. Lelieveldt; Y. Bartels; R. Hammink; K.A.J. van Schie; R.E.M. Toes; K.M. Bonger; H.Ulrich Scherer

Year of Publication: 2022

Correction to: Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents Iris

I.M. Hagemans; P.J. Wierstra; K. Steuten; J.D.M. Molkenboer-Kuenen; D. van Dalen; Mter Beest; J.M.S. van der Schoot; O. Ilina; M. Gotthardt; C.G. Figdor; F.A. Scheeren; S. Heskamp; M. Verdoes

Year of Publication: 2022

Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells

M. Mensink; E. Schrama; E. Cuadrado; D. Amsen; S. de Kivit; J. Borst

Year of Publication: 2022

TNFR2 Costimulation Differentially Impacts Regulatory and Conventional CD4+ T-Cell Metabolism

M. Mensink; T.Ngoc Minh Tran; E.A. Zaal; E. Schrama; C.R. Berkers; J. Borst; S. de Kivit

Year of Publication: 2022

Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis

S. Kroos; A.S.B. Kampstra; R.E.M. Toes; L.M. Slot; H.U. Scherer

Year of Publication: 2022

Inhibition of H1 and H5 Influenza A Virus Entry by Diverse Macrocyclic Peptides Targeting the Hemagglutinin Stem Region

M.N. Pascha; V. Thijssen; J.E. Egido; M.W. Linthorst; J.H. van Lanen; D.A.A. van Dongen; A.J.P. Hopstaken; F.J.M. van Kuppeveld; J. Snijder; C.A.M. de Haan; S.A.K. Jongkees

Year of Publication: 2022

Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37

R. Peeters; J. Cuenca-Escalona; E.A. Zaal; A.T. Hoekstra; A.C.G. Balvert; M. Vidal-Manrique; N. Blomberg; S.J. van Deventer; R. Stienstra; J. Jellusova; M. Giera; L. Hannibal; U. Spiekerkoetter; Mter Beest; C.R. Berkers; A.B. van Spriel

Year of Publication: 2022

CRISPR Activation Screening Identifies VGLL3–TEAD1–RUNX1/3 as a Transcriptional Complex for PD-L1 Expression

R.H. Wijdeven; B. Cabukusta; F.M. Behr; X. Qiu; D. Amiri; D.M. Borràs; R. Arens; Y. Liang; J. Neefjes

Year of Publication: 2022

Glycan shield of the ebolavirus envelope glycoprotein GP

W. Peng; V. Rayaprolu; A.D. Parvate; M.F. Pronker; S. Hui; D. Parekh; K. Shaffer; X. Yu; E.O. Saphire; J. Snijder

Year of Publication: 2022

Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion

C. Le Gall; A. Cammarata; L. de Haas; I. Ramos-Tomillero; J. Cuenca-Escalona; K. Schouren; Z. Wijfjes; A.M.D. Becker; J. Bödder; Y. Dolen; J.M. de Vries; C.G. Figdor; G. Flórez-Grau; M. Verdoes

Year of Publication: 2022

Chemical Probes to Control and Visualize Lipid Metabolism in the Brain

J.M. Punt; D. van der Vliet; M. van der Stelt

Year of Publication: 2022

Frequency chasing of individual megadalton ions in an Orbitrap analyser improves precision of analysis in single-molecule mass spectrometry

T.P. Wörner; K. Aizikov; J. Snijder; K.L. Fort; A.A. Makarov; A.J.R. Heck

Year of Publication: 2022

Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire Profiling

D. Schulte; W. Peng; J. Snijder

Year of Publication: 2022

Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents

I.M. Hagemans; P.J. Wierstra; K. Steuten; J.D.M. Molkenboer-Kuenen; D. van Dalen; Mter Beest; J.M.S. van der Schoot; O. Ilina; M. Gotthardt; C.G. Figdor; F.A. Scheeren; S. Heskamp; M. Verdoes

Year of Publication: 2022

RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency

J.E. Stok; T. Oosenbrug; L.R. Haar; D. Gravekamp; C.P. Bromley; S. Zelenay; C.Reis e Sousa; A.G. Veen

Year of Publication: 2022

Lipid A analog CRX-527 conjugated to synthetic peptides enhances vaccination efficacy and tumor control

E. Tondini; N.R.M. Reintjens; G. Castello; T. Arakelian; M. Isendoorn; M. Camps; J. Vree; G.A. van der Marel; D.V. Filippov; J.D.C. Codée; F. Ossendorp

Year of Publication: 2022

Dictating Phenotype, Function, and Fate of Human T Cells with Co‐Stimulatory Antibodies Presented by Filamentous Immune Cell Mimics

M. Schluck; L.J. Eggermont; J. Weiden; C. Popelier; L. Weiss; B. Pilzecker; S. Kolder; A. Heinemans; C.Rodriguez Mogeda; M. Verdoes; C.G. Figdor; R. Hammink

Year of Publication: 2022

Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ

D. Torres-García; M.A.T. van de Plassche; E. van Boven; T. van Leeuwen; M.G.J. Groenewold; A.J.C. Sarris; L. Klein; H.S. Overkleeft; S.I. van Kasteren

Year of Publication: 2022

Live‐Cell Imaging of Sterculic Acid—a Naturally Occurring 1,2‐Cyclopropene Fatty Acid—by Bioorthogonal Reaction with Turn‐On Tetrazine‐Fluorophore Conjugates

K. Bertheussen; M. van de Plassche; T. Bakkum; B. Gagestein; I. Ttofi; A.J.C. Sarris; H.S. Overkleeft; M. van der Stelt; S.I. van Kasteren

Year of Publication: 2022

Non-Genetic Generation of Antibody Conjugates Based on Chemoenzymatic Tyrosine Click Chemistry

J.J. Bruins; J.A.M. Damen; M.A. Wijdeven; L.P.W.M. Lelieveldt; F.L. van Delft; B. Albada

Year of Publication: 2021

Application of a Highly Selective Cathepsin S Two-step Activity-Based Probe in Multicolor Bio-Orthogonal Correlative Light-Electron MicroscopyDataSheet1.docxpresentation1.pptx

F.J. van Dalen; T. Bakkum; T. van Leeuwen; M. Groenewold; E. Deu; A.J. Koster; S.I. van Kasteren; M. Verdoes

Year of Publication: 2021

HLA Class II Presentation Is Specifically Altered at Elevated Temperatures in the B-Lymphoblastic Cell Line JY

L.C. Demmers; W. Wu; A.J.R. Heck

Year of Publication: 2021

Super-resolution correlative light-electron microscopy using a click-chemistry approach for studying intracellular trafficking

T. Andrian; T. Bakkum; D.M. van Elsland; E. Bos; A.J. Koster; L. Albertazzi; S.I. van Kasteren; S. Pujals

Year of Publication: 2021

Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions

G. Dudas; S.L. Hong; B.I. Potter; S. Calvignac-Spencer; F.S. Niatou-Singa; T.B. Tombolomako; T. Fuh-Neba; U. Vickos; M. Ulrich; F.H. Leendertz; K. Khan; C. Huber; A. Watts; I. Olendraitė; J. Snijder; K.N. Wijnant; A.M.J.J. Bonvin; P. Martres; S. Behillil; A. Ayouba; M.Foudi Maidadi; D.Meta Djomsi; C. Godwe; C. Butel; A. Šimaitis; M. Gabrielaitė; M. Katėnaitė; R. Norvilas; L. Raugaitė; G.Wilfried Koyaweda; J.Kaleb Kandou; R. Jonikas; I. Nasvytienė; Ž. Žemeckienė; D. Gečys; K. Tamušauskaitė; M. Norkienė; E. Vasiliūnaitė; D. Žiogienė; A. Timinskas; M. Šukys; M. Šarauskas; G. Alzbutas; A.Amuri Aziza; E.Kinganda Lusamaki; J.C.Makangara Cigolo; F.Muyembe Mawete; E.Lokilo Lofiko; P.Mbala Kingebeni; J.J.Muyembe Tamfum; M.Roseline D. Belizaire; R.Ghislain Essomba; M.Claire Oko Assoumou; A.Blaise Mboringong; A.Baba Dieng; D. Juozapaitė; S. Hosch; J. Obama; M.Ondo’o Ayekaba; D. Naumovas; A. Pautienius; C.Donatien Rafaï; A. Vitkauskienė; R. Ugenskienė; A. Gedvilaitė; D. Čereškevičius; V. Lesauskaitė; L. Žemaitis; L. Griškevičius; G. Baele

Year of Publication: 2021

Adeno-associated virus capsid assembly is divergent and stochastic

T.P. Wörner; A. Bennett; S. Habka; J. Snijder; O. Friese; T. Powers; M. Agbandje-McKenna; A.J.R. Heck

Year of Publication: 2021

Allotype-Specific Glycosylation and Cellular Localization of Human Leukocyte Antigen Class I Proteins

M. Hoek; L.C. Demmers; W. Wu; A.J.R. Heck

Year of Publication: 2021

Synthetic (N,N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs

D.P.A. Wander; S.Y. van der Zanden; M.B.L. Vriends; B.C. van Veen; J.G.C. Vlaming; T. Bruyning; T. Hansen; G.A. van der Marel; H.S. Overkleeft; J.J.C. Neefjes; J.D.C. Codée

Year of Publication: 2021

Semiflexible Immunobrushes Induce Enhanced T Cell Activation and Expansion

R. Hammink; J. Weiden; D. Voerman; C. Popelier; L.J. Eggermont; M. Schluck; C.G. Figdor; M. Verdoes

Year of Publication: 2021

Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

D. Horn-Ghetko; D.T. Krist; R. Prabu; K. Baek; M.P.C. Mulder; M. Klügel; D.C. Scott; H. Ovaa; G. Kleiger; B.A. Schulman

Year of Publication: 2021

Distinct antigen uptake receptors route to the same storage compartments for cross‐presentation in dendritic cells

N.I. Ho; M.G. Camps; J.J. Garcia‐Vallejo; E. Bos; A.J. Koster; M. Verdoes; Y. Kooyk; F. Ossendorp

Year of Publication: 2021

Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α

A. Ottria; M. Zimmermann; L.M. Paardekooper; T. Carvalheiro; N. Vazirpanah; S. Silva-Cardoso; A.J. Affandi; E. Chouri; Mv.d Kroef; R.G. Tieland; C.P.J. Bekker; C.G.K. Wichers; M. Rossato; E. Mocholi-Gimeno; J. Tekstra; E. Ton; J.M. van Laar; M. Cossu; L. Beretta; S.Garcia Perez; A. Pandit; F. Bonte-Mineur; K.A. Reedquist; G. van den Bogaart; T.R.D.J. Radstake; W. Marut

Year of Publication: 2021

Dual Site-Specific Chemoenzymatic Antibody Fragment Conjugation Using CRISPR-Based Hybridoma Engineering

C.M. Le Gall; J.M.S. van der Schoot; I. Ramos-Tomillero; M.Parlak Khalily; F.J. van Dalen; Z. Wijfjes; L. Smeding; D. van Dalen; A. Cammarata; K.M. Bonger; C.G. Figdor; F.A. Scheeren; M. Verdoes

Year of Publication: 2021

Human plasma IgG1 repertoires are simple, unique, and dynamic

A. Bondt; M. Hoek; S. Tamara; B. de Graaf; W. Peng; D. Schulte; D.M.H. van Rijswijck; M.A. den Boer; J.F. Greisch; M.R.J. Varkila; J. Snijder; O.L. Cremer; M.J.M. Bonten; A.J.R. Heck

Year of Publication: 2021

Quantitative Phosphoproteomic Analysis Reveals Dendritic Cell- Specific STAT Signaling After α2-3–Linked Sialic Acid Ligand Binding

R.J.Eveline Li; A. de Haas; E. Rodriguez; H. Kalay; A. Zaal; C.R. Jimenez; S.R. Piersma; T.V. Pham; A.A. Henneman; R.R. de Goei de Haas; S.J. van Vliet; Y. van Kooyk

Year of Publication: 2021

Single-cell analysis of regions of interest (SCARI) using a photosensitive tag

A.M. van der Leun; M.E. Hoekstra; L. Reinalda; C.L.G.J. Scheele; M. Toebes; M.J. van de Graaff; L.Y.Y. Chen; H. Li; A. Bercovich; Y. Lubling; E. David; D.S. Thommen; A. Tanay; J. van Rheenen; I. Amit; S.I. van Kasteren; T.N. Schumacher

Year of Publication: 2021

α2-3 Sialic acid binding and uptake by human monocyte-derived dendritic cells alters metabolism and cytokine release and initiates tolerizing T cell programming

J. Lübbers; R.J.Eveline Li; F.S. Gorki; S.C.M. Bruijns; A. Gallagher; H. Kalay; M. Ambrosini; D. Molenaar; J. Van den Bossche; S.J. van Vliet; Y. van Kooyk

Year of Publication: 2021

Targeting coenzyme Q10 synthesis overcomes bortezomib resistance in multiple myeloma

E.A. Zaal; H.J. de Grooth; I. Oudaert; P. Langerhorst; S. Levantovsky; G.J.J. van Slobbe; J.W.A. Jansen; E. Menu; W. Wu; C.R. Berkers

Year of Publication: 2021

The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02

S. Mukherjee; A. Sanchez-Bernabeu; L.C. Demmers; W. Wu; A.J.R. Heck

Year of Publication: 2021

Mass Spectrometry-Based De Novo Sequencing of Monoclonal Antibodies Using Multiple Proteases and a Dual Fragmentation Scheme

W. Peng; M.F. Pronker; J. Snijder

Year of Publication: 2021

Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT

R. Riera; T.P. Hogervorst; W. Doelman; Y. Ni; S. Pujals; E. Bolli; J.D.C. Codée; S.I. van Kasteren; L. Albertazzi

Year of Publication: 2021

Recent developments in bioorthogonal chemistry and the orthogonality within

M.L.W.J. Smeenk; J. Agramunt; K.M. Bonger

Year of Publication: 2021

New insights into the activities and toxicities of the old anticancer drug doxorubicin

S.Y. van der Zanden; X. Qiao; J. Neefjes

Year of Publication: 2021

Dynamic Plasma Membrane Organization: A Complex Symphony

S. van Deventer; A.B. Arp; A.B. van Spriel

Year of Publication: 2021

A Direct MS-Based Approach to Profile Human Milk Secretory Immunoglobulin A (IgA1) Reveals Donor-Specific Clonal Repertoires With High Longitudinal Stability

A. Bondt; K.A. Dingess; M. Hoek; D.M.H. van Rijswijck; A.J.R. Heck

Year of Publication: 2021

Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens

T. van Leeuwen; C. Araman; L.Pieper Pournara; A.S.B. Kampstra; T. Bakkum; M.H.S. Marqvorsen; C.R. Nascimento; G.J.Mirjam Groenewold; W. van der Wulp; M.G.M. Camps; G.M.C. Janssen; P.A. van Veelen; G.J.P. van Westen; A.P.A. Janssen; B.I. Florea; H.S. Overkleeft; F.A. Ossendorp; R.E.M. Toes; S.I. van Kasteren

Year of Publication: 2021

Glycoproteoform Profiles of Individual Patients’ Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode

T. Caval; Y.H. Lin; M. Varkila; K.R. Reiding; M.J.M. Bonten; O.L. Cremer; V. Franc; A.J.R. Heck

Year of Publication: 2021

Clickable Vitamins as a New Tool to Track Vitamin A and Retinoic Acid in Immune Cells

A.V. Bos; M.N. Erkelens; S.T.A. Koenders; M. van der Stelt; M. van Egmond; R.E. Mebius

Year of Publication: 2021

Mass Spectrometry-Based Structural Virology

T.P. Wörner; T.M. Shamorkina; J. Snijder; A.J.R. Heck

Year of Publication: 2021

The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle‐down characterization of antibodies

T. Caval; E.S. Hecht; W. Tang; M. Uy‐Gomez; A. Nichols; Y.J. Kil; W. Sandoval; M. Bern; A.J.R. Heck

Year of Publication: 2021

Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots

J. Weiden; M. Schluck; M. Ioannidis; E.A.W. van Dinther; M. Rezaeeyazdi; F. Omar; J. Steuten; D. Voerman; J. Tel; M. Diken; S.A. Bencherif; C.G. Figdor; M. Verdoes

Year of Publication: 2021

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

K.M. Bouwman; I. Tomris; H.L. Turner; R. van der Woude; T.M. Shamorkina; G.P. Bosman; B. Rockx; S. Herfst; J. Snijder; B.L. Haagmans; A.B. Ward; G.J. Boons; R.P. de Vries

Year of Publication: 2021

Enhanced Antitumor Efficacy through an “AND gate” Reactive Oxygen‐Species‐Dependent pH‐Responsive Nanomedicine Approach

E. Jäger; J. Humajová; Y. Dolen; J. Kučka; A. Jäger; R. Konefał; J. Pankrác; E. Pavlova; T. Heizer; L. Šefc; M. Hrubý; C.G. Figdor; M. Verdoes

Year of Publication: 2021

Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

B.J. Hos; M.G.M. Camps; J. van den Bulk; E. Tondini; T.C. van den Ende; D. Ruano; K. Franken; G.M.C. Janssen; A. Ru; D.V. Filippov; R. Arens; P.A. van Veelen; N. Miranda; F. Ossendorp

Year of Publication: 2020

Meta-heterogeneity: evaluating and describing the diversity in glycosylation between sites on the same glycoprotein

T. Caval; A.J.R. Heck; K.R. Reiding

Year of Publication: 2020

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

H. Kristyanto; N.J. Blomberg; L.M. Slot; E.I.H. van der Voort; P.F. Kerkman; A. Bakker; L.E. Burgers; R.M. ten Brinck; A.H.M. van van Mil; H. Spits; D.L. Baeten; T.W.J. Huizinga; R.E.M. Toes; H.U. Scherer

Year of Publication: 2020

The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

S. Di Blasio; G.F. van Wigcheren; A. Becker; A. van Duffelen; M. Gorris; K. Verrijp; I. Stefanini; G.J. Bakker; M. Bloemendal; A. Halilovic; A. Vasaturo; G. Bakdash; S.V. Hato; J.H.W. de Wilt; J. Schalkwijk; I.J.M. de Vries; J.C. Textor; E.H. van den Bogaard; M. Tazzari; C.G. Figdor

Year of Publication: 2020

Balancing STING in antimicrobial defense and autoinflammation

S.L. Landman; M.E. Ressing; A.G. van der Veen

Year of Publication: 2020

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin

X. Qiao; S.Y. van der Zanden; D.P.A. Wander; D.M. Borràs; J.Y. Song; X. Li; S. van Duikeren; N. van Gils; A. Rutten; T. van Herwaarden; O. van Tellingen; E. Giacomelli; M. Bellin; V. Orlova; L.G.J. Tertoolen; S. Gerhardt; J.J. Akkermans; J.M. Bakker; C.L. Zuur; B. Pang; A.M. Smits; C.L. Mummery; L. Smit; R. Arens; J. Li; H.S. Overkleeft; J. Neefjes

Year of Publication: 2020

Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens

R.J.Eveline Li; T.P. Hogervorst; S. Achilli; S.C.M. Bruijns; S. Spiekstra; C. Vivès; M. Thépaut; D.V. Filippov; G.A. van der Marel; S.J. van Vliet; F. Fieschi; J.D.C. Codée; Y. van Kooyk

Year of Publication: 2020

Opportunities for Small Molecules in Cancer Immunotherapy

S.Y. van der Zanden; J.J. Luimstra; J. Neefjes; J. Borst; H. Ovaa

Year of Publication: 2020

Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry

T.P. Wörner; J. Snijder; A. Bennett; M. Agbandje-McKenna; A.A. Makarov; A.J.R. Heck

Year of Publication: 2020

Site‐specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9

V. Neviani; S. van Deventer; T.P. Wörner; K.T. Xenaki; M. van de Waterbeemd; R.N.P. Rodenburg; I.M.N. Wortel; J.K. Kuiper; S. Huisman; J. Granneman; P.M.P. van Henegouwen; A.J.R. Heck; A.B. van Spriel; P. Gros

Year of Publication: 2020

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications

T. Kissel; S. Reijm; L.M. Slot; M. Cavallari; C.M. Wortel; R.D. Vergroesen; G. Stoeken-Rijsbergen; J.C. Kwekkeboom; A.S.B. Kampstra; E.W.N. Levarht; J.W. Drijfhout; H. Bang; K.M. Bonger; G.M.C. Janssen; P.A. van Veelen; T.W.J. Huizinga; H.U. Scherer; M. Reth; R.E.M. Toes

Year of Publication: 2020

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

W. Oosterheert; K.T. Xenaki; V. Neviani; W. Pos; S. Doulkeridou; J. Manshande; N.M. Pearce; L.M.J. Kroon-Batenburg; M. Lutz; P.M.P. van Ber Henegouwen; P. Gros

Year of Publication: 2020

Bioorthogonal Correlative Light-Electron Microscopy of Mycobacterium tuberculosis in Macrophages Reveals the Effect of Antituberculosis Drugs on Subcellular Bacterial Distribution

T. Bakkum; M.T. Heemskerk; E. Bos; M. Groenewold; N. Oikonomeas-Koppasis; K.V. Walburg; S. van Veen; M.J.C. van der Lienden; T. van Leeuwen; M.C. Haks; T.H.M. Ottenhoff; A.J. Koster; S.I. van Kasteren

Year of Publication: 2020

GPA33: A Marker to Identify Stable Human Regulatory T Cells

R. Opstelten; S. de Kivit; M.C. Slot; M. van den Biggelaar; D. Iwaszkiewicz-Grześ; M. Gliwiński; A.M. Scott; B. Blom; P. Trzonkowski; J. Borst; E. Cuadrado; D. Amsen

Year of Publication: 2020

A mouse model that is immunologically tolerant to reporter and modifier proteins

K. Bresser; F.E. Dijkgraaf; C.E.J. Pritchard; I.J. Huijbers; J.Y. Song; J.C. Rohr; F.A. Scheeren; T.N. Schumacher

Year of Publication: 2020

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

E.D. Mock; M. Mustafa; O. Gunduz-Cinar; R. Cinar; G.N. Petrie; V. Kantae; X. Di; D. Ogasawara; Z.V. Varga; J. Paloczi; C. Miliano; G. Donvito; A.C.M. van Esbroeck; A.M.F. van der Gracht; I. Kotsogianni; J.K. Park; A. Martella; T. van der Wel; M. Soethoudt; M. Jiang; T.J. Wendel; A.P.A. Janssen; A.T. Bakker; C.M. Donovan; L.I. Castillo; B.I. Florea; J. Wat; H. van den Hurk; M. Wittwer; U. Grether; A. Holmes; C.A.A. van Boeckel; T. Hankemeier; B.F. Cravatt; M.W. Buczynski; M.N. Hill; P. Pacher; A.H. Lichtman; M. van der Stelt

Year of Publication: 2020

Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes

D.W. Poramba-Liyanage; T. Korthout; C.E. Cucinotta; I. van Kruijsbergen; T. van Welsem; D.El Atmioui; H. Ovaa; T. Tsukiyama; F. van Leeuwen

Year of Publication: 2020

Immune involvement of the contralateral hemisphere in a glioblastoma mouse model

M.H.W. Crommentuijn; S.T.T. Schetters; S.A. Dusoswa; L.J.W. Kruijssen; J.J. Garcia-Vallejo; Y. van Kooyk

Year of Publication: 2020

Strategy for Development of Site-Specific Ubiquitin Antibodies

I. van Kruijsbergen; M.P.C. Mulder; M. Uckelmann; T. van Welsem; J. de Widt; A. Spanjaard; H. Jacobs; F.El Oualid; H. Ovaa; F. van Leeuwen

Year of Publication: 2020

Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the lac repressor

M.A.R. de Geus; G.J.Mirjam Groenewold; E. Maurits; C. Araman; S.I. van Kasteren

Year of Publication: 2020

Bioorthogonal Reactions in Activity-Based Protein Profiling

S.H.L. Verhelst; K.M. Bonger; L.I. Willems

Year of Publication: 2020

Fluorogenic Bifunctional trans‐Cyclooctenes as Efficient Tools for Investigating Click‐to‐Release Kinetics

M.A.R. de Geus; E. Maurits; A.J.C. Sarris; T. Hansen; M.S. Kloet; K. Kamphorst; Wten Hoeve; M.S. Robillard; A. Pannwitz; S.A. Bonnet; J.D.C. Codée; D.V. Filippov; H.S. Overkleeft; S.I. van Kasteren

Year of Publication: 2020

Toll-like receptor signaling induces a temporal switch towards a resolving lipid profile in monocyte-derived macrophages

J.H. von Hegedus; A.S. Kahnt; R. Ebert; M. Heijink; R.E.M. Toes; M. Giera; A. Ioan-Facsinay

Year of Publication: 2020

Activatable cell-penetrating peptides: 15 years of research

H. de Jong; K.M. Bonger; D.W.P.M. Löwik

Year of Publication: 2020

Doxorubicin and Aclarubicin: Shuffling Anthracycline Glycans for Improved Anticancer Agents

D.P.A. Wander; S.Y. van der Zanden; G.A. van der Marel; H.S. Overkleeft; J. Neefjes; J.D.C. Codée

Year of Publication: 2020

IFN-Stimulated Gene 15 Is an Alarmin that Boosts the CTL Response via an Innate, NK Cell–Dependent Route

V. Iglesias-Guimarais; T. Ahrends; E. de Vries; K.P. Knobeloch; A. Volkov; J. Borst

Year of Publication: 2020

Design of TLR2-ligand-synthetic long peptide conjugates for therapeutic vaccination of chronic HBV patients

Y. Dou; D.T.S.L. Jansen; A. van den Bosch; R.A. de Man; N. van Montfoort; C. Araman; S.I. van Kasteren; G.G. Zom; W.J. Krebber; C.J.M. Melief; A.M. Woltman; S.I. Buschow

Year of Publication: 2020

Activation of the C-Type Lectin MGL by Terminal GalNAc Ligands Reduces the Glycolytic Activity of Human Dendritic Cells

A. Zaal; R.J.Eveline Li; J. Lübbers; S.C.M. Bruijns; H. Kalay; Y. van Kooyk; S.J. van Vliet

Year of Publication: 2020

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

L.C. Demmers; K. Kretzschmar; A. Van Hoeck; Y.E. Bar-Epraïm; H.W.P. van den Toorn; M. Koomen; G. van Son; J. van Gorp; A. Pronk; N. Smakman; E. Cuppen; H. Clevers; A.J.R. Heck; W. Wu

Year of Publication: 2020

Immunoproteasome Inhibitor–Doxorubicin Conjugates Target Multiple Myeloma Cells and Release Doxorubicin upon Low-Dose Photon Irradiation

E. Maurits; M.J. van de Graaff; S. Maiorana; D.P.A. Wander; P.M. Dekker; S.Y. van der Zanden; B.I. Florea; J.J.C. Neefjes; H.S. Overkleeft; S.I. van Kasteren

Year of Publication: 2020

Glioblastomas exploit truncated O-linked glycans for local and distant immune modulation via the macrophage galactose-type lectin

S.A. Dusoswa; J. Verhoeff; E. Abels; S.P. Méndez-Huergo; D.O. Croci; L.H. Kuijper; E. de Miguel; V.M.C.J. Wouters; M.G. Best; E. Rodriguez; L.A.M. Cornelissen; S.J. van Vliet; P. Wesseling; X.O. Breakefield; D.P. Noske; T. Würdinger; M.L.D. Broekman; G.A. Rabinovich; Y. van Kooyk; J.J. Garcia-Vallejo

Year of Publication: 2020

Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling

M.N. Erkelens; G. Goverse; T. Konijn; R. Molenaar; M.R. Beijer; J. Van den Bossche; K.E. de Goede; S.G.S. Verberk; W.J. de Jonge; J.M.M. den Haan; R.E. Mebius

Year of Publication: 2020

Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation

S. de Kivit; M. Mensink; A.T. Hoekstra; I. Berlin; R.J.E. Derks; D. Both; M.A. Aslam; D. Amsen; C.R. Berkers; J. Borst

Year of Publication: 2020

STA‐55, an Easily Accessible, Broad‐Spectrum, Activity‐Based Aldehyde Dehydrogenase Probe

S.T.A. Koenders; E.J. van Rooden; H. van den Elst; B.I. Florea; H.S. Overkleeft; M. van der Stelt

Year of Publication: 2020

Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans

D.L. Hurdiss; I. Drulyte; Y. Lang; T.M. Shamorkina; M.F. Pronker; F.J.M. van Kuppeveld; J. Snijder; R.J. de Groot

Year of Publication: 2020

C-Mannosyl Lysine for Solid Phase Assembly of Mannosylated Peptide Conjugate Cancer Vaccines

T.P. Hogervorst; R.J.Eveline Li; L. Marino; S.C.M. Bruijns; N.J. Meeuwenoord; D.V. Filippov; H.S. Overkleeft; G.A. van der Marel; S.J. van Vliet; Y. van Kooyk; J.D.C. Codée

Year of Publication: 2020

Self RNA Sensing by RIG-I–like Receptors in Viral Infection and Sterile Inflammation

J.E. Stok; E.Vega Quiroz; A.G. van der Veen

Year of Publication: 2020

An efficient synthesis of a 6″-BODIPY-α-Galactosylceramide probe for monitoring α-Galactosylceramide uptake by cells

J.M.H. Cheng; S.H. Chee; Y. Dolen; M. Verdoes; M.S.M. Timmer; B.L. Stocker

Year of Publication: 2019

Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells

S. Duinkerken; E. Li; F.J. van Haften; T.D. de Gruijl; F. Chiodo; S.T.T. Schetters; Y. van Kooyk

Year of Publication: 2019

Glycan modification of glioblastoma‐derived extracellular vesicles enhances receptor‐mediated targeting of dendritic cells

S.A. Dusoswa; S.K. Horrevorts; M. Ambrosini; H. Kalay; N.J. Paauw; R. Nieuwland; M.D. Pegtel; T. Würdinger; Y. van Kooyk; J.J. Garcia‐Vallejo

Year of Publication: 2019

Molecular Repolarisation of Tumour-Associated Macrophages

F.J. van Dalen; M.H.M.E. Van Stevendaal; F.L. Fennemann; M. Verdoes; O. Ilina

Year of Publication: 2019

Attacking Tumors From All Sides: Personalized Multiplex Vaccines to Tackle Intratumor Heterogeneity

F.L. Fennemann; J.M. de Vries; C.G. Figdor; M. Verdoes

Year of Publication: 2019

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

J.M.S. van der Schoot; F.L. Fennemann; M. Valente; Y. Dolen; I.M. Hagemans; A.M.D. Becker; C.M. Le Gall; D. van Dalen; A. Cevirgel; J.A.C. van Bruggen; M. Engelfriet; T. Caval; A.E.H. Bentlage; M.F. Fransen; M. Nederend; J.H.W. Leusen; A.J.R. Heck; G. Vidarsson; C.G. Figdor; M. Verdoes; F.A. Scheeren

Year of Publication: 2019

Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7

G.P.P. Gential; T.P. Hogervorst; E. Tondini; M.J. van de Graaff; H.S. Overkleeft; J.D.C. Codée; G.A. van der Marel; F. Ossendorp; D.V. Filippov

Year of Publication: 2019

Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties

B.T. Xin; J. Gan; D.J. Fernandez; K.P. Knobeloch; P.P. Geurink; H. Ovaa

Year of Publication: 2019

Vinylboronic acid-caged prodrug activation using click-to-release tetrazine ligation

L.P.W.M. Lelieveldt; S. Eising; A. Wijen; K.M. Bonger

Year of Publication: 2019

Cross-talk between iNKT cells and CD8 T cells in the spleen requires the IL-4/CCL17 axis for the generation of short-lived effector cells

M. Valente; Y. Dölen; E. van Dinther; L. Vimeux; M. Fallet; V. Feuillet; C.G. Figdor

Year of Publication: 2019

Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen

R.J.Eveline Li; T.P. Hogervorst; S. Achilli; S.C. Bruijns; T. Arnoldus; C. Vivès; C.C. Wong; M. Thépaut; N.J. Meeuwenoord; H. van den Elst; H.S. Overkleeft; G.A. van der Marel; D.V. Filippov; S.J. van Vliet; F. Fieschi; J.D.C. Codée; Y. van Kooyk

Year of Publication: 2019

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

M.E.W. Logtenberg; J.H.Marco Jansen; M. Raaben; M. Toebes; K. Franke; A.M. Brandsma; H.L. Matlung; A. Fauster; R. Gomez-Eerland; N.A.M. Bakker; S. van der Schot; K.A. Marijt; M. Verdoes; J.B.A.G. Haanen; J.H. van den Berg; J. Neefjes; T.K. van den Berg; T.R. Brummelkamp; J.H.W. Leusen; F.A. Scheeren; T.N. Schumacher

Year of Publication: 2019

Synthetic Semiflexible and Bioactive Brushes

D. Voerman; M. Schluck; J. Weiden; B. Joosten; L.J. Eggermont; T. van den Eijnde; B. Ignacio; A. Cambi; C.G. Figdor; P.H.J. Kouwer; M. Verdoes; R. Hammink; A.E. Rowan

Year of Publication: 2019

Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells

S.T.A. Koenders; L.S. Wijaya; M.N. Erkelens; A.T. Bakker; V.E. van der Noord; E.J. van Rooden; L. Burggraaff; P.C. Putter; E. Botter; K. Wals; H. van den Elst; Hden Dulk; B.I. Florea; B. van de Water; G.J.P. van Westen; R.E. Mebius; H.S. Overkleeft; S.E. Le Dévédec; M. van der Stelt

Year of Publication: 2019

Going Native: Synthesis of Glycoproteins and Glycopeptides via Native Linkages To Study Glycan-Specific Roles in the Immune System

M.H.S. Marqvorsen; C. Araman; S.I. van Kasteren

Year of Publication: 2019

Oxygen in the tumor microenvironment: effects on dendritic cell function

L.M. Paardekooper; W. Vos; G. van den Bogaart

Year of Publication: 2019

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

D.W. Vredevoogd; T. Kuilman; M.A. Ligtenberg; J. Boshuizen; K.E. Stecker; B. de Bruijn; O. Krijgsman; X. Huang; J.C.N. Kenski; R. Lacroix; R. Mezzadra; R. Gomez-Eerland; M. Yildiz; I. Dagidir; G. Apriamashvili; N. Zandhuis; V. van der Noort; N.L. Visser; C.U. Blank; M. Altelaar; T.N. Schumacher; D.S. Peeper

Year of Publication: 2019

Imaging of T-cells and their responses during anti-cancer immunotherapy

M. Krekorian; G.O. Fruhwirth; M. Srinivas; C.G. Figdor; S. Heskamp; T.H. Witney; E.H.J.G. Aarntzen

Year of Publication: 2019

Pre-fractionation Extends but also Creates a Bias in the Detectable HLA Class Ι Ligandome

L.C. Demmers; A.J.R. Heck; W. Wu

Year of Publication: 2019

Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells

M. Schluck; R. Hammink; C.G. Figdor; M. Verdoes; J. Weiden

Year of Publication: 2019

Production and Thermal Exchange of Conditional Peptide‐MHC I Multimers

J.J. Luimstra; K.L.M.C. Franken; M.A. Garstka; J.W. Drijfhout; J. Neefjes; H. Ovaa

Year of Publication: 2019

Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second

L.M. Paardekooper; I. Dingjan; P.T.A. Linders; A.H.J. Staal; S.M. Cristescu; W.C.E.P. Verberk; G. van den Bogaart

Year of Publication: 2019

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

J. Marcandalli; B. Fiala; S. Ols; M. Perotti; W. de van der Schueren; J. Snijder; E. Hodge; M. Benhaim; R. Ravichandran; L. Carter; W. Sheffler; L. Brunner; M. Lawrenz; P. Dubois; A. Lanzavecchia; F. Sallusto; K.K. Lee; D. Veesler; C.E. Correnti; L.J. Stewart; D. Baker; K. Loré; L. Perez; N.P. King

Year of Publication: 2019

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

A.C. Walls; X. Xiong; Y.J. Park; A. Tortorici; J. Snijder; J. Quispe; E. Cameroni; R. Gopal; M. Dai; A. Lanzavecchia; M. Zambon; F.A. Rey; D. Corti; D. Veesler

Year of Publication: 2019

Neurodegeneration meets immunology – A chemical biology perspective

C. Araman; B.A.'t Hart

Year of Publication: 2019

Amyloid-like Behavior of Site-Specifically Citrullinated Myelin Oligodendrocyte Protein (MOG) Peptide Fragments inside EBV-Infected B-Cells Influences Their Cytotoxicity and Autoimmunogenicity

C. Araman; M.E. van Gent; N.J. Meeuwenoord; N. Heijmans; M.H.S. Marqvorsen; W. Doelman; B.W. Faber; B.A. ’t Hart; S.I. van Kasteren

Year of Publication: 2019

Highly Efficient Mono-Functionalization of Knob-in-Hole Antibodies with Strain-Promoted Click Chemistry

J.J. Bruins; C. van de Wouw; K. Wagner; L. Bartels; B. Albada; F.L. van Delft

Year of Publication: 2019

Simply Extending the Mass Range in Electron Transfer Higher Energy Collisional Dissociation Increases Confidence in N-Glycopeptide Identification

T. Caval; J. Zhu; A.J.R. Heck

Year of Publication: 2019

Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes

A.M.F. van der Gracht; M.A.R. de Geus; M.G.M. Camps; T.J. Ruckwardt; A.J.C. Sarris; J. Bremmers; E. Maurits; J.B. Pawlak; M.M. Posthoorn; K.M. Bonger; D.V. Filippov; H.S. Overkleeft; M.S. Robillard; F. Ossendorp; S.I. van Kasteren

Year of Publication: 2018

Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes

T. Bakkum; T. van Leeuwen; A.J.C. Sarris; D.M. van Elsland; D. Poulcharidis; H.S. Overkleeft; S.I. van Kasteren

Year of Publication: 2018

Orthogonal, dual protein labelling by tandem cycloaddition of strained alkenes and alkynes to ortho-quinones and azides

J.J. Bruins; D. Blanco-Ania; V. van der Doef; F.L. van Delft; B. Albada

Year of Publication: 2018

Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells

M. Soethoudt; S.C. Stolze; M.V. Westphal; L. van Stralen; A. Martella; E.J. van Rooden; W. Guba; Z.V. Varga; H. Deng; S.I. van Kasteren; U. Grether; A.P. IJzerman; P. Pacher; E.M. Carreira; H.S. Overkleeft; A. Ioan-Facsinay; L.H. Heitman; M. van der Stelt

Year of Publication: 2018

The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases

V. Chiurchiù; M. van der Stelt; D. Centonze; M. Maccarrone

Year of Publication: 2018

Approaches to Improve Chemically Defined Synthetic Peptide Vaccines

B.J. Hos; E. Tondini; S.I. van Kasteren; F. Ossendorp

Year of Publication: 2018

Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells

L.P.W.M. Lelieveldt; H. Kristyanto; G.J.M. Pruijn; H.Ulrich Scherer; R.E.M. Toes; K.M. Bonger

Year of Publication: 2018

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

C. Stathopoulou; A. Gangaplara; G. Mallett; F.A. Flomerfelt; L.P. Liniany; D. Knight; L.A. Samsel; R. Berlinguer-Palmini; J.J. Yim; T.C. Felizardo; M.A. Eckhaus; L. Edgington-Mitchell; J. Martinez-Fabregas; J. Zhu; D.H. Fowler; S.I. van Kasteren; A. Laurence; M. Bogyo; C. Watts; E.M. Shevach; S. Amarnath

Year of Publication: 2018

Using the glycan toolbox for pathogenic interventions and glycan immunotherapy

R.J.Eveline Li; S.J. van Vliet; Y. van Kooyk

Year of Publication: 2018

Endolysosomal-Escape Nanovaccines through Adjuvant-Induced Tumor Antigen Assembly for Enhanced Effector CD8+ T Cell Activation

L. Qiu; M. Valente; Y. Dolen; E. Jäger; Mter Beest; L. Zheng; C.G. Figdor; M. Verdoes

Year of Publication: 2018

Antigen Processing and Cross-Presentation

J.B. Pawlak; S.I. van Kasteren

Year of Publication: 2018

Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?

J. Liepe; H. Ovaa; M. Mishto

Year of Publication: 2018

Toll-like Receptor Agonist Conjugation: A Chemical Perspective

B.J. Ignacio; T.J. Albin; A.P. Esser-Kahn; M. Verdoes

Year of Publication: 2018

Targeted analysis of lysosomal directed proteins and their sites of mannose-6-phosphate modification

T. Caval; J. Zhu; W. Tian; S.N. Remmelzwaal; Z. Yang; H. Clausen; A.J.R. Heck

Year of Publication: 2018

Trophoblast Glycoprotein is Associated With a Favorable Outcome for Mesothelioma and a Target for Antibody Drug Conjugates

L.M. Schunselaar; K. Monkhorst; V. van der Noort; R. Wijdeven; D. Peters; W. Zwart; J. Neefjes; P. Baas

Year of Publication: 2018

Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

D. Ugurlar; S.C. Howes; B.J. de Kreuk; R.I. Koning; R.N. de Jong; F.J. Beurskens; J. Schuurman; A.J. Koster; T.H. Sharp; P.W.H.I. Parren; P. Gros

Year of Publication: 2018

Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor alpha via MAP3K8

L.M. Paardekooper; M.B. Bendix; A. Ottria; L.W. de Haer; Mter Beest; T.R.D.J. Radstake; W. Marut; G. van den Bogaart

Year of Publication: 2018

Chemical Profiling of Primary Mesothelioma Cultures Defines Subtypes with Different Expression Profiles and Clinical Responses

L.M. Schunselaar; J.M.M.F. Quispel-Janssen; Y. Kim; C. Alifrangis; W. Zwart; P. Baas; J. Neefjes

Year of Publication: 2018

A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells

J.J. Luimstra; M.A. Garstka; M.C.J. Roex; A. Redeker; G.M.C. Janssen; P.A. van Veelen; R. Arens; J.H.Frederik Falkenburg; J. Neefjes; H. Ovaa

Year of Publication: 2018

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

T. van Welsem; T. Korthout; R. Ekkebus; D. Morais; T.M. Molenaar; K. van Harten; D.W. Poramba-Liyanage; S.Ming Sun; T.L. Lenstra; R. Srivas; T. Ideker; F.C.P. Holstege; H. van Attikum; F.El Oualid; H. Ovaa; I.J.E. Stulemeijer; H. Vlaming; F. van Leeuwen

Year of Publication: 2018

ortho-Quinones and Analogues Thereof: Highly Reactive Intermediates for Fast and Selective Biofunctionalization

J.J. Bruins; B. Albada; F. van Delft

Year of Publication: 2018

Injectable Biomimetic Hydrogels as Tools for Efficient T Cell Expansion and Delivery

J. Weiden; D. Voerman; Y. Dolen; R.K. Das; A. van Duffelen; R. Hammink; L.J. Eggermont; A.E. Rowan; J. Tel; C.G. Figdor

Year of Publication: 2018

Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

E. Cuadrado; M. van den Biggelaar; S. de Kivit; Yyen Chen; M. Slot; I. Doubal; A. Meijer; R.A.W. van Lier; J. Borst; D. Amsen

Year of Publication: 2018

Chemical and genetic control of IFN gamma-induced MHCII expression

R.H. Wijdeven; M.M. van Luijn; A.F. Wierenga‐Wolf; J.J. Akkermans; P.J. van den Elsen; R.Q. Hintzen; J. Neefjes

Year of Publication: 2018

Approaches to Improve Chemically Defined Synthetic Peptide Vaccines

B.J. Hos; E. Tondini; S.I. van Kasteren; F. Ossendorp

Year of Publication: 2018

Direct quality control of glycoengineered erythropoietin variants

T. Caval; W. Tian; Z. Yang; H. Clausen; A.J.R. Heck

Year of Publication: 2018

Fast and pH independent elimination of trans-cyclooctene using aminoethyl functionalized tetrazines

A.J.C. Sarris; T. Hansen; M.A.R. de Geus; E. Maurits; W. Doelman; H.S. Overkleeft; J.D.C. Codee; D. Filippov; S.I. van Kasteren

Year of Publication: 2018

Creating molecules that modulate immune responses

S.I. van Kasteren; J. Neefjes; H. Ovaa

Year of Publication: 2018

Ultrastructural Imaging of Salmonella-Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens

D.M. van Elsland; S. Pujals; T. Bakkum; E. Bos; N. Oikonomeas-Koppasis; I. Berlin; J. Neefjes; A.H. Meijer; A.J. Koster; L. Albertazzi; S.I. van Kasteren

Year of Publication: 2018

Metabolic response of porcine colon explants to in vitro infection by Brachyspira hyodysenteriae: a leap into disease pathophysiology

T. Welle; A.T. Hoekstra; I.A.J.J.M. Daemen; C.R. Berkers; M.O. Costa

Year of Publication: 2017

Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases

M.P. Baggelaar; A.C.M. van Esbroeck; E.J. van Rooden; B.I. Florea; H.S. Overkleeft; G. Marsicano; F. Chaouloff; M. van der Stelt

Year of Publication: 2017

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

X. Xue; J. Wu; D. Ricklin; F. Forneris; P. Di Crescenzio; C.Q. Schmidt; J. Granneman; T.H. Sharp; J.D. Lambris; P. Gros

Year of Publication: 2017

Chemoenzymatic Approach for the Preparation of Asymmetric Bi-, Tri-, and Tetra-Antennary N-Glycans from a Common Precursor

I.A. Gagarinov; T. Li; J.Sastre Toraño; T. Caval; A.D. Srivastava; J.A.W. Kruijtzer; A.J.R. Heck; G.J. Boons

Year of Publication: 2017

Ethylene, an early marker of systemic inflammation in humans

L.M. Paardekooper; G. van den Bogaart; M. Kox; I. Dingjan; A.H. Neerincx; M.B. Bendix; Mter Beest; F.J.M. Harren; T. Risby; P. Pickkers; N. Marczin; S.M. Cristescu

Year of Publication: 2017

Arginine (Di)methylated Human Leukocyte Antigen Class I Peptides Are Favorably Presented by HLA-B*07

F. Marino; G.P.M. Mommen; A. Jeko; H.D. Meiring; J.A.M. van van den Brink; R.A. Scheltema; C.A.C.M. van Els; A.J.R. Heck

Year of Publication: 2017

Synthetic immune niches for cancer immunotherapy

J. Weiden; J. Tel; C.G. Figdor

Year of Publication: 2017

The EGFR odyssey – from activation to destruction in space and time

J. Bakker; M. Spits; J. Neefjes; I. Berlin

Year of Publication: 2017

Elucidating crosstalk mechanisms between phosphorylation and O-GlcNAcylation

A.C. Leney; D.El Atmioui; W. Wu; H. Ovaa; A.J.R. Heck

Year of Publication: 2017

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

R. Mezzadra; C. Sun; L.T. Jae; R. Gomez-Eerland; E. de Vries; W. Wu; M.E.W. Logtenberg; M. Slagter; E.A. Rozeman; I. Hofland; A. Broeks; H.M. Horlings; L.F.A. Wessels; C.U. Blank; Y. Xiao; A.J.R. Heck; J. Borst; T.R. Brummelkamp; T.N.M. Schumacher

Year of Publication: 2017

A membrane-anchored aptamer sensor for probing IFNγ secretion by single cells

L. Qiu; F. Wimmers; J. Weiden; H.A. Heus; J. Tel; C.G. Figdor

Year of Publication: 2017

Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry

R.N.P. Rodenburg; J. Snijder; M. van de Waterbeemd; A. Schouten; J. Granneman; A.J.R. Heck; P. Gros

Year of Publication: 2017

Imaging complement by phase-plate cryo-electron tomography from initiation to pore formation

T.H. Sharp; F.G.A. Faas; A.J. Koster; P. Gros

Year of Publication: 2017

Inducible, Site-Specific Protein Labeling by Tyrosine Oxidation–Strain-Promoted (4 + 2) Cycloaddition

J.J. Bruins; A.H. Westphal; B. Albada; K. Wagner; L. Bartels; H. Spits; W.J.H. van Berkel; F.L. van Delft

Year of Publication: 2017

Correlative light and electron microscopy reveals discrepancy between gold and fluorescence labelling

D.M. VAN ELSLAND; E. BOS; J.B. PAWLAK; H.S. OVERKLEEFT; A.J. KOSTER; S.I. VAN KASTEREN

Year of Publication: 2017

Retinoic Acid and Immune Homeostasis: A Balancing Act

M.N. Erkelens; R.E. Mebius

Year of Publication: 2017

A molecular basis for the presentation of phosphorylated peptides by HLA-B antigens

A. Alpízar; F. Marino; A. Ramos-Fernández; M. Lombardía; A. Jeko; F. Pazos; A. Paradela; C. Santiago; A.J.R. Heck; M. Marcilla

Year of Publication: 2016

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope

A. Textor; K. Schmidt; P.M. Kloetzel; B. Weißbrich; C. Perez; J. Charo; K. Anders; J. Sidney; A. Sette; T.N.M. Schumacher; C. Keller; D.H. Busch; U. Seifert; T. Blankenstein

Year of Publication: 2016

A large fraction of HLA class I ligands are proteasome-generated spliced peptides

J. Liepe; F. Marino; J. Sidney; A. Jeko; D.E. Bunting; A. Sette; P.M. Kloetzel; M.P.H. Stumpf; A.J.R. Heck; M. Mishto

Year of Publication: 2016

SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis

M.V. Baranov; N.H. Revelo; I. Dingjan; R. Maraspini; Mter Beest; A. Honigmann; G. van den Bogaart

Year of Publication: 2016

Structural basis of myelin-associated glycoprotein adhesion and signalling

M.F. Pronker; S. Lemstra; J. Snijder; A.J.R. Heck; D.M.E. Thies-Weesie; J. Pasterkamp; B.J.C. Janssen

Year of Publication: 2016

The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes

J.B. Pawlak; B.J. Hos; M.J. van de Graaff; O.A. Megantari; N. Meeuwenoord; H.S. Overkleeft; D.V. Filippov; F. Ossendorp; S.I. van Kasteren

Year of Publication: 2016

Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics

R.H. Wijdeven; B. Pang; Y.G. Assaraf; J. Neefjes

Year of Publication: 2016

Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein

A. Jagessar; I.R. Holtman; S. Hofman; E. Morandi; N. Heijmans; J.D. Laman; B. Gran; B.W. Faber; S.I. van Kasteren; B.J.L. Eggen; B.A. ‘t Hart

Year of Publication: 2016

A toolbox for controlling the properties and functionalisation of hydrazone-based supramolecular hydrogels

J.M. Poolman; C. Maity; J. Boekhoven; L. van der Mee; V.A.A. le Sage; G.J.Mirjam Groenewold; S.I. van Kasteren; F. Versluis; J.H. van Esch; R. Eelkema

Year of Publication: 2016

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

R.H. Wijdeven; H. Janssen; L. Nahidiazar; L. Janssen; K. Jalink; I. Berlin; J. Neefjes

Year of Publication: 2016

Imaging Bioorthogonal Groups in Their Ultrastructural Context with Electron Microscopy

D.M. van Elsland; S.I. van Kasteren

Year of Publication: 2016

Variations in MHC Class II Antigen Processing and Presentation in Health and Disease

E.R. Unanue; V. Turk; J. Neefjes

Year of Publication: 2016

Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance

S.K.Rosenda Huber; J.J. Luimstra; J. van Beek; R. Hoppes; R.H.J. Jacobi; M. Hendriks; K. Kapteijn; C. Ouwerkerk; B. Rodenko; H. Ovaa; J. de Jonge

Year of Publication: 2016

Synthetic and semi-synthetic strategies to study ubiquitin signaling

G.B.A. van Tilburg; A.F. Elhebieshy; H. Ovaa

Year of Publication: 2016

Detection of bioorthogonal groups by correlative light and electron microscopy allows imaging of degraded bacteria in phagocytes

D.M. van Elsland; E. Bos; W. de Boer; H.S. Overkleeft; A.J. Koster; S.I. van Kasteren

Year of Publication: 2016

Sampling from the proteome to the HLA-DR ligandome proceeds via high specificity

G.P.M. Mommen; F. Marino; H.D. Meiring; M.C.M. Poelen; J.A.M. van G. van den Brink; S. Mohammed; A.J.R. Heck; C.A.C.M. van Els

Year of Publication: 2016

Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib

G. de Bruin; E.D. Mock; S. Hoogendoorn; A.M.C.H. van den Nieuwendijk; J. Mazurek; G.A. van der Marel; B.I. Florea; H.S. Overkleeft

Year of Publication: 2016

Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis

P.F. Kerkman; E. Fabre; E.I.H. van der Voort; A. Zaldumbide; Y. Rombouts; T. Rispens; G. Wolbink; R.C. Hoeben; H. Spits; D.L.P. Baeten; T.W.J. Huizinga; R.E.M. Toes; H.U. Scherer

Year of Publication: 2016

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition.

A. Banno; D.A. Garcia; E.D. van Baarsel; P.J. Metz; K. Fisch; C.E. Widjaja; S.H. Kim; J. Lopez; A.N. Chang; P.P. Geurink; B.I. Florea; H.S. Overkleeft; H. Ovaa; J.D. Bui; J. Yang; J.T. Chang

Year of Publication: 2016

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

G. Wang; R. N. de Jong; E. T.J. van den Bremer; F. J. Beurskens; A. F. Labrijn; D. Ugurlar; P. Gros; J. Schuurman; P. W.H.I. Parren; A. J.R. Heck

Year of Publication: 2016

Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP)

C. De Nardis; P. Lössl; M. van den Biggelaar; P.K. Madoori; N. Leloup; K. Mertens; A.J.R. Heck; P. Gros

Year of Publication: 2016

N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging.

S. van Deventer; V. Menendez-Benito; F. van Leeuwen; J. Neefjes

Year of Publication: 2015

Peptide Splicing in the Proteasome Creates a Novel Type of Antigen with an Isopeptide Linkage.

C.R. Berkers; A. de Jong; K.G. Schuurman; C. Linnemann; J.A.J. Geenevasen; T.N.M. Schumacher; B. Rodenko; H. Ovaa

Year of Publication: 2015

Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules.

C.R. Berkers; A. de Jong; K.G. Schuurman; C. Linnemann; H.D. Meiring; L. Janssen; J.J. Neefjes; T.N.M. Schumacher; B. Rodenko; H. Ovaa

Year of Publication: 2015

Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer

R.H. Wijdeven; B. Pang; S.Y. van der Zanden; X. Qiao; V. Blomen; M. Hoogstraat; E.H. Lips; L. Janssen; L. Wessels; T.R. Brummelkamp; J. Neefjes

Year of Publication: 2015

ER contact sites direct late endosome transport

R.H. Wijdeven; M.L.M. Jongsma; J. Neefjes; I. Berlin

Year of Publication: 2015

The first step of peptide selection in antigen presentation by MHC class I molecules.

M.A. Garstka; A. Fish; P.H.N. Celie; R.P. Joosten; G.M.C. Janssen; I. Berlin; R. Hoppes; M. Stadnik; L. Janssen; H. Ovaa; P.A. van Veelen; A. Perrakis; J. Neefjes

Year of Publication: 2015

Characterization of the mammalian CORVET and HOPS complexes and their modular restructuring for endosome specificity.

R. van der Kant; C.T.H. Jonker; R.H. Wijdeven; J. Bakker; L. Janssen; J. Klumperman; J. Neefjes

Year of Publication: 2015

Polymer-based synthetic dendritic cells for tailoring robust and multifunctional T cell responses.

S. Mandal; R. Hammink; J. Tel; Z.H. Eksteen-Akeroyd; A.E. Rowan; K. Blank; C.G. Figdor

Year of Publication: 2015

Extended O-GlcNAc on HLA Class-I-Bound Peptides

F. Marino; M. Bern; G.P.M. Mommen; A.C. Leney; J.A.M. van van den Brink; A.M.J.J. Bonvin; C. Becker; C.A.C.M. van Els; A.J.R. Heck

Year of Publication: 2015

Chemical profiling of the genome with anti-cancer drugs defines target specificities.

B. Pang; J. de Jong; X. Qiao; L.F.A. Wessels; J. Neefjes

Year of Publication: 2015

Bioorthogonal deprotection on the dendritic cell surface for chemical control of antigen cross-presentation.

J.B. Pawlak; G.P.P. Gential; T.J. Ruckwardt; J.S. Bremmers; N.J. Meeuwenoord; F.A. Ossendorp; H.S. Overkleeft; D.V. Filippov; S.I. van Kasteren

Year of Publication: 2015

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma.

T. Scanu; R.M. Spaapen; J.M. Bakker; C.Bhan Pratap; Len Wu; I. Hofland; A. Broeks; V.Kumar Shukla; M. Kumar; H. Janssen; J.Y. Song; A. Neefjes-Borst; Hte Riele; D.W. Holden; G. Nath; J. Neefjes

Year of Publication: 2015

Chemical biology of antigen presentation by MHC molecules.

S.I. van Kasteren; H. Overkleeft; H. Ovaa; J. Neefjes

Year of Publication: 2014

How chemistry supports cell biology: the chemical toolbox at your service.

R.H. Wijdeven; J. Neefjes; H. Ovaa

Year of Publication: 2014

The right touch: design of artificial antigen-presenting cells to stimulate the immune system

J. van der Weijden; L.E. Paulis; M. Verdoes; J.C.M. van Hest; C.G. Figdor

Year of Publication: 2014

50 years of Dutch immunology – Founders, institutions, highlights

F.H.J. Gmelig-Meyling; L. Meyaard; R.E. Mebius

Year of Publication: 2014

Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.

A.T. Ghisaidoobe; R.J.B.H.N. van den Berg; S.S. Butt; A. Strijland; W.E. Donker-Koopman; S. Scheij; A.M.C.H. van den Nieuwendijk; G.J. Koomen; A. van Loevezijn; M. Leemhuis; T. Wennekes; M. van der Stelt; G.A. van der Marel; C.A.A. van Boeckel; J.M.F.G. Aerts; H.S. Overkleeft

Year of Publication: 2014

Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD).

G.P.M. Mommen; C.K. Frese; H.D. Meiring; Jvan Gaans van den Brink; A.P.J.M. de Jong; C.A.C.M. van Els; A.J.R. Heck

Year of Publication: 2014