Esther ter Linden

PhD student
Cell and Chemical Biology
Research activities: 

In this project we aim to get a better understanding of the controlling mechanisms of endosomal biology as a target for small molecule-mediated modulation of immune responses. We continue our research on a previous finding of our lab; how reversible ubiquitylation of Rab7 controls its function in the endo-lysosomal system.

Our aims are: identifying the E2/E3 ligase(s) responsible for Rab GTPase ubiquitylation; studying how reversible ubiquitylation of Rab GTPases controls the display of cycling immune proteins and ultimately showing how modulation of endosomal traffic by small molecules affects cytotoxic granule production and secretion in T-cells.