Multiple sclerosis (MS) is characterized by neuroinflammation and demyelinating lesions within the central nervous system. Therapeutic targets include protecting against new inflammation and promoting remyelination of axons. Modulation of endocannabinoid signaling lipids leads to profound changes in brain lipid metabolism and has been shown to reduce neuroinflammation.
This project will investigate the functional properties of the microglial mechanisms and endocannabinoid lipid metabolism in mouse models of demyelination. Novel fluorescent probes will be used to visualize changes in lipase activity in living animals. We aim to better understand inflammatory lesions to help guide the development of new therapies for MS.