Molecular Cell Biology and Immunology
Thesis: Unleashing glycan immune checkpoint in PDAC via targeting tumor/stroma
Pancreatic adenocarcinoma is accounted as the most case of Pancreatic cancers with a non-immunogenic, immune- suppressive and therapy resistant tumor microenvironment (TME). Our hypothesis is that one of the reason of immune suppressive characteristic of this cancer could be the alteration of glycosylation patterns, especially overexpression of sialic acid during malignancy transformation. The aim of this project is targeting of sialic acid in tumor and stroma, since the most mass of tumor microenvironment composed of stroma, then profiling of immune cells in TME.