Sabrina Krepel

The Herpesviridae family consist of a wide array of disease-inducing viruses, including herpes simplex virus (HSV-1) and cytomegalovirus (CMV). The ability of these neurotropic viruses to enter the central nervous system attests to a specific interaction between exposed proteins of the host with viral fusion proteins. To study the interaction mechanism between herpesvirus particles and host cells, structural studies on fusion glycoprotein B and its possible target MAG (myelin-associated glycoprotein) will be central to this project. Additional insights may be gained from other target identification via a proteomics approach and immunological studies on glycoprotein B.